2PBI

The multifunctional nature of Gbeta5/RGS9 revealed from its crystal structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
A	0035556	biological_process	intracellular signal transduction
B	0007165	biological_process	signal transduction
C	0007186	biological_process	G protein-coupled receptor signaling pathway
C	0008277	biological_process	regulation of G protein-coupled receptor signaling pathway
C	0035556	biological_process	intracellular signal transduction
D	0007165	biological_process	signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 904

Chain	Residue
A	TYR107
A	PHE108
A	ASP120
A	TYR187
A	HOH917
A	HOH965

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 905

Chain	Residue
B	PHE51
B	VAL52
A	ILE260
A	MET261
B	GLN50

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 906

Chain	Residue
A	GLY263
A	CYS264
A	SER267
A	ASN268
A	ILE271
A	HOH927
A	HOH1008

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL B 902

Chain	Residue
B	ALA158
B	CYS200
B	LEU201
B	ARG246
B	HOH910
B	HOH913
B	HOH940
B	HOH943
B	HOH955

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL B 909

Chain	Residue
A	ASN299
A	SER301
A	ARG305
A	HOH963
B	GLU207
B	PRO249
B	SER250

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 907

Chain	Residue
C	ARG235
C	SER236
C	THR237
D	GLN233
D	LEU268
D	HOH1044

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL D 901

Chain	Residue
D	ALA158
D	CYS200
D	LEU201
D	ARG246
D	HOH919
D	HOH923
D	HOH924
D	HOH951
D	HOH956

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D 903

Chain	Residue
C	SER301
C	ARG305
C	HOH924
D	PRO205
D	SER206
D	GLU207
D	PRO249
D	SER250

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL D 908

Chain	Residue
D	GLU27
D	HIS34
D	PHE235
D	ASP271
D	HOH989
D	HOH1078
D	HOH1109

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. IVSSsqDgKVIVWDS

Chain	Residue	Details
B	ILE78-SER92
B	ILE168-VAL182
B	LEU298-VAL312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	150
Details	Domain: {"description":"DEP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00066","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	122
Details	Domain: {"description":"G protein gamma"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	230
Details	Domain: {"description":"RGS","evidences":[{"source":"PROSITE-ProRule","id":"PRU00171","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	78
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	78
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	82
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	84
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	78
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	84
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	58
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

---