2OZA
Structure of p38alpha complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0000077 | biological_process | DNA damage checkpoint signaling |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000902 | biological_process | cell morphogenesis |
| B | 0000922 | cellular_component | spindle pole |
| B | 0001502 | biological_process | cartilage condensation |
| B | 0001525 | biological_process | angiogenesis |
| B | 0001649 | biological_process | osteoblast differentiation |
| B | 0001890 | biological_process | placenta development |
| B | 0002021 | biological_process | response to dietary excess |
| B | 0002062 | biological_process | chondrocyte differentiation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004707 | molecular_function | MAP kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006006 | biological_process | glucose metabolic process |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0006915 | biological_process | apoptotic process |
| B | 0006974 | biological_process | DNA damage response |
| B | 0007178 | biological_process | cell surface receptor protein serine/threonine kinase signaling pathway |
| B | 0007519 | biological_process | skeletal muscle tissue development |
| B | 0010628 | biological_process | positive regulation of gene expression |
| B | 0010831 | biological_process | positive regulation of myotube differentiation |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016607 | cellular_component | nuclear speck |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018105 | biological_process | peptidyl-serine phosphorylation |
| B | 0019395 | biological_process | fatty acid oxidation |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0019903 | molecular_function | protein phosphatase binding |
| B | 0030278 | biological_process | regulation of ossification |
| B | 0030316 | biological_process | osteoclast differentiation |
| B | 0031098 | biological_process | stress-activated protein kinase signaling cascade |
| B | 0031281 | biological_process | positive regulation of cyclase activity |
| B | 0031663 | biological_process | lipopolysaccharide-mediated signaling pathway |
| B | 0032495 | biological_process | response to muramyl dipeptide |
| B | 0032496 | biological_process | response to lipopolysaccharide |
| B | 0032735 | biological_process | positive regulation of interleukin-12 production |
| B | 0032868 | biological_process | response to insulin |
| B | 0033209 | biological_process | tumor necrosis factor-mediated signaling pathway |
| B | 0035331 | biological_process | negative regulation of hippo signaling |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0035924 | biological_process | cellular response to vascular endothelial growth factor stimulus |
| B | 0035994 | biological_process | response to muscle stretch |
| B | 0038066 | biological_process | p38MAPK cascade |
| B | 0042307 | biological_process | positive regulation of protein import into nucleus |
| B | 0042770 | biological_process | signal transduction in response to DNA damage |
| B | 0045648 | biological_process | positive regulation of erythrocyte differentiation |
| B | 0045663 | biological_process | positive regulation of myoblast differentiation |
| B | 0045944 | biological_process | positive regulation of transcription by RNA polymerase II |
| B | 0046326 | biological_process | positive regulation of D-glucose import |
| B | 0046777 | biological_process | protein autophosphorylation |
| B | 0048010 | biological_process | vascular endothelial growth factor receptor signaling pathway |
| B | 0048273 | molecular_function | mitogen-activated protein kinase p38 binding |
| B | 0051146 | biological_process | striated muscle cell differentiation |
| B | 0051403 | biological_process | stress-activated MAPK cascade |
| B | 0051525 | molecular_function | NFAT protein binding |
| B | 0051604 | biological_process | protein maturation |
| B | 0060043 | biological_process | regulation of cardiac muscle cell proliferation |
| B | 0060045 | biological_process | positive regulation of cardiac muscle cell proliferation |
| B | 0060348 | biological_process | bone development |
| B | 0070269 | biological_process | pyroptotic inflammatory response |
| B | 0071222 | biological_process | cellular response to lipopolysaccharide |
| B | 0071223 | biological_process | cellular response to lipoteichoic acid |
| B | 0071356 | biological_process | cellular response to tumor necrosis factor |
| B | 0071479 | biological_process | cellular response to ionizing radiation |
| B | 0071493 | biological_process | cellular response to UV-B |
| B | 0090090 | biological_process | negative regulation of canonical Wnt signaling pathway |
| B | 0090336 | biological_process | positive regulation of brown fat cell differentiation |
| B | 0090400 | biological_process | stress-induced premature senescence |
| B | 0098586 | biological_process | cellular response to virus |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0099179 | biological_process | regulation of synaptic membrane adhesion |
| B | 0106310 | molecular_function | protein serine kinase activity |
| B | 1900015 | biological_process | regulation of cytokine production involved in inflammatory response |
| B | 1901741 | biological_process | positive regulation of myoblast fusion |
| B | 1904784 | biological_process | NLRP1 inflammasome complex assembly |
| B | 2000379 | biological_process | positive regulation of reactive oxygen species metabolic process |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 24 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGLGINGKVLqIfnkrtqek..........FALK |
| Chain | Residue | Details |
| A | LEU70-LYS93 | |
| B | VAL30-LYS54 |
| site_id | PS00108 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IaHrDVKpeNLLY |
| Chain | Residue | Details |
| A | ILE182-TYR194 |
| site_id | PS01351 |
| Number of Residues | 104 |
| Details | MAPK MAP kinase signature. FqsiihakrtyRElrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltddhvqfliyqilrglkyihsadiih.........RDlKpsnlavnedC |
| Chain | Residue | Details |
| B | PHE59-CYS162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 36 |
| Details | Region: {"description":"Autoinhibitory helix","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | Region: {"description":"p38 MAPK-binding site"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 9 |
| Details | Motif: {"description":"Nuclear export signal (NES)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Motif: {"description":"Bipartite nuclear localization signal 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Bipartite nuclear localization signal 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAPK14","evidences":[{"source":"PubMed","id":"8846784","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)","evidences":[{"source":"PubMed","id":"21131586","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by MAP2K3, MAP2K4, MAP2K6 and autocatalysis","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine; by ZAP70","evidences":[{"source":"UniProtKB","id":"Q16539","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | SER154 | |
| B | ASP150 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP186 | |
| A | GLU190 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS152 | |
| B | ASP150 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP186 | |
| A | LYS188 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS152 | |
| B | THR185 | |
| B | ASP150 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | THR226 | |
| A | ASP186 | |
| A | LYS188 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | ASN155 | |
| B | LYS152 | |
| B | ASP150 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | ASP186 | |
| A | ASN191 | |
| A | LYS188 |
