2ORV

human Thymidine Kinase 1 in complex with TP4A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004797	molecular_function	thymidine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0008270	molecular_function	zinc ion binding
A	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0042802	molecular_function	identical protein binding
A	0046104	biological_process	thymidine metabolic process
A	0046105	biological_process	thymidine biosynthetic process
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0071897	biological_process	DNA biosynthetic process
A	1904860	biological_process	DNA synthesis involved in mitotic DNA replication
B	0000166	molecular_function	nucleotide binding
B	0004797	molecular_function	thymidine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0008270	molecular_function	zinc ion binding
B	0009157	biological_process	deoxyribonucleoside monophosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0042802	molecular_function	identical protein binding
B	0046104	biological_process	thymidine metabolic process
B	0046105	biological_process	thymidine biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0071897	biological_process	DNA biosynthetic process
B	1904860	biological_process	DNA synthesis involved in mitotic DNA replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 235

Chain	Residue
A	CYS153
A	CYS156
A	CYS185
A	CYS188

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 235

Chain	Residue
B	CYS153
B	CYS156
B	CYS185
B	CYS188

---

site_id	AC3
Number of Residues	30
Details	BINDING SITE FOR RESIDUE 4TA A 801

Chain	Residue
A	PHE29
A	SER30
A	GLY31
A	LYS32
A	SER33
A	ASP58
A	ARG60
A	ASP97
A	GLU98
A	GLN100
A	PHE101
A	LEU124
A	THR127
A	PHE128
A	PHE133
A	VAL172
A	GLU173
A	VAL174
A	ILE175
A	GLY176
A	TYR181
A	HOH806
A	HOH810
A	HOH823
A	HOH831
A	HOH846
A	HOH863
A	HOH868
A	HOH880
A	MET28

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE 4TA B 802

Chain	Residue
B	MET28
B	PHE29
B	SER30
B	GLY31
B	LYS32
B	SER33
B	ASP58
B	ASP97
B	GLU98
B	GLN100
B	PHE101
B	LEU124
B	THR127
B	PHE128
B	PHE133
B	THR163
B	ARG165
B	VAL172
B	GLU173
B	VAL174
B	ILE175
B	GLY176
B	TYR181
B	HOH808
B	HOH821
B	HOH834
B	HOH872

---

Functional Information from PROSITE/UniProt

site_id	PS00603
Number of Residues	14
Details	TK_CELLULAR_TYPE Thymidine kinase cellular-type signature. GgaDkYhSvCRlCY

Chain	Residue	Details
A	GLY176-TYR189

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611477","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15733844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17407781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22385435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ORV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WVJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611477","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15733844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22385435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WVJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15733844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22385435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2WVJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15611477","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15733844","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17407781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22385435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W4R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ORV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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