2O1S
1-deoxy-D-xylulose 5-phosphate synthase (DXS) from Escherichia coli
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006744 | biological_process | ubiquinone biosynthetic process |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0008615 | biological_process | pyridoxine biosynthetic process |
| A | 0008661 | molecular_function | 1-deoxy-D-xylulose-5-phosphate synthase activity |
| A | 0009228 | biological_process | thiamine biosynthetic process |
| A | 0016114 | biological_process | terpenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0052865 | biological_process | obsolete 1-deoxy-D-xylulose 5-phosphate biosynthetic process |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006744 | biological_process | ubiquinone biosynthetic process |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0008615 | biological_process | pyridoxine biosynthetic process |
| B | 0008661 | molecular_function | 1-deoxy-D-xylulose-5-phosphate synthase activity |
| B | 0009228 | biological_process | thiamine biosynthetic process |
| B | 0016114 | biological_process | terpenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0052865 | biological_process | obsolete 1-deoxy-D-xylulose 5-phosphate biosynthetic process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006744 | biological_process | ubiquinone biosynthetic process |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0008615 | biological_process | pyridoxine biosynthetic process |
| C | 0008661 | molecular_function | 1-deoxy-D-xylulose-5-phosphate synthase activity |
| C | 0009228 | biological_process | thiamine biosynthetic process |
| C | 0016114 | biological_process | terpenoid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| C | 0030976 | molecular_function | thiamine pyrophosphate binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0052865 | biological_process | obsolete 1-deoxy-D-xylulose 5-phosphate biosynthetic process |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006744 | biological_process | ubiquinone biosynthetic process |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0008615 | biological_process | pyridoxine biosynthetic process |
| D | 0008661 | molecular_function | 1-deoxy-D-xylulose-5-phosphate synthase activity |
| D | 0009228 | biological_process | thiamine biosynthetic process |
| D | 0016114 | biological_process | terpenoid biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0019288 | biological_process | isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0052865 | biological_process | obsolete 1-deoxy-D-xylulose 5-phosphate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 1001 |
| Chain | Residue |
| A | ASP152 |
| A | ASN181 |
| A | TPP3001 |
| A | HOH3137 |
| A | HOH3138 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 2001 |
| Chain | Residue |
| A | PRO413 |
| A | GLY464 |
| A | TYR465 |
| A | TYR467 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1002 |
| Chain | Residue |
| B | ASP152 |
| B | ASN179 |
| B | ASN181 |
| B | DPO4001 |
| B | HOH4130 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K B 2002 |
| Chain | Residue |
| B | PRO413 |
| B | GLY464 |
| B | TYR465 |
| B | TYR467 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 1003 |
| Chain | Residue |
| C | ASP152 |
| C | ASN181 |
| C | LYS284 |
| C | TPP3002 |
| C | HOH3121 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 2003 |
| Chain | Residue |
| C | PRO413 |
| C | GLY464 |
| C | TYR465 |
| C | TYR467 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 1004 |
| Chain | Residue |
| D | ASP152 |
| D | ASN181 |
| D | DPO4002 |
| D | HOH4113 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K D 2004 |
| Chain | Residue |
| D | PRO413 |
| D | GLY464 |
| D | TYR465 |
| D | TYR467 |
| site_id | AC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TPP A 3001 |
| Chain | Residue |
| A | SER52 |
| A | HIS80 |
| A | GLY121 |
| A | HIS122 |
| A | SER123 |
| A | GLY151 |
| A | ASP152 |
| A | GLY153 |
| A | ALA154 |
| A | ASN181 |
| A | TYR288 |
| A | ALA345 |
| A | MSE346 |
| A | ILE368 |
| A | GLU370 |
| A | PHE395 |
| A | ARG398 |
| A | MG1001 |
| A | HOH3100 |
| A | HOH3141 |
| A | HOH3158 |
| site_id | BC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DPO B 4001 |
| Chain | Residue |
| B | HIS80 |
| B | GLY151 |
| B | ASP152 |
| B | GLY153 |
| B | ALA154 |
| B | ASN181 |
| B | MG1002 |
| site_id | BC2 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE TPP C 3002 |
| Chain | Residue |
| C | HIS80 |
| C | GLY121 |
| C | HIS122 |
| C | SER123 |
| C | GLY151 |
| C | ASP152 |
| C | GLY153 |
| C | ALA154 |
| C | ASN181 |
| C | LYS284 |
| C | TYR288 |
| C | ALA345 |
| C | MSE346 |
| C | ILE368 |
| C | GLU370 |
| C | PHE395 |
| C | ARG398 |
| C | MG1003 |
| C | HOH3121 |
| C | HOH3129 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DPO D 4002 |
| Chain | Residue |
| D | HIS80 |
| D | GLY151 |
| D | ASP152 |
| D | GLY153 |
| D | ALA154 |
| D | ASN181 |
| D | MG1004 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17135236","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | GLU370 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| D | GLU370 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| C | GLU370 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | GLU370 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | HIS431 | |
| A | GLU370 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | HIS431 | |
| B | GLU370 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| C | HIS431 | |
| C | GLU370 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| D | HIS431 | |
| D | GLU370 |
| site_id | CSA9 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | PRO253 |
| site_id | CSA10 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | PRO253 |
| site_id | CSA11 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| C | PRO253 |
| site_id | CSA12 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| D | PRO253 |
| site_id | CSA13 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| A | PHE248 |
| site_id | CSA14 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| B | PHE248 |
| site_id | CSA15 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| C | PHE248 |
| site_id | CSA16 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1dtw |
| Chain | Residue | Details |
| D | PHE248 |
