2NS7

How an in vitro selected peptide mimics the antibiotic tetracycline to induce TET repressor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0006355	biological_process	regulation of DNA-templated transcription
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0006355	biological_process	regulation of DNA-templated transcription
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0046677	biological_process	response to antibiotic
B	0046872	molecular_function	metal ion binding
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0006355	biological_process	regulation of DNA-templated transcription
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0006355	biological_process	regulation of DNA-templated transcription
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0046677	biological_process	response to antibiotic
D	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS01081
Number of Residues	32
Details	HTH_TETR_1 TetR-type HTH domain signature. GIeglTTrkLaqklgVEqPtLYwHVkNKralL

Chain	Residue	Details
A	GLY21-LEU52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	76
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00335

Chain	Residue	Details
A	THR26-VAL45
B	THR26-VAL45
C	THR26-VAL45
D	THR26-VAL45

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site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0ACT4

Chain	Residue	Details
A	HIS64
D	HIS64
D	ASN82
D	HIS100
A	ASN82
A	HIS100
B	HIS64
B	ASN82
B	HIS100
C	HIS64
C	ASN82
C	HIS100

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