2NRU

Crystal structure of IRAK-4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007165	biological_process	signal transduction
B	0000287	molecular_function	magnesium ion binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0007165	biological_process	signal transduction
C	0000287	molecular_function	magnesium ion binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0007165	biological_process	signal transduction
D	0000287	molecular_function	magnesium ion binding
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0007165	biological_process	signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 611

Chain	Residue
B	SER423
C	LYS174
D	ASN207

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 612

Chain	Residue
A	ALA421
A	ASP422
A	SER423
C	ASN207

---

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE T12 A 600

Chain	Residue
A	ALA211
A	LYS213
A	TYR262
A	VAL263
A	TYR264
A	MET265
A	PRO266
A	ASN267
A	GLY268
A	ARG273
A	LEU318
A	HOH630
A	HOH673
A	MET192
A	VAL200

---

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE T12 B 601

Chain	Residue
B	VAL200
B	ALA211
B	LYS213
B	TYR262
B	VAL263
B	TYR264
B	MET265
B	PRO266
B	ASN267
B	GLY268
B	ARG273
B	LEU318
B	HOH636
B	HOH669
B	HOH681

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE T12 C 602

Chain	Residue
C	ILE185
C	MET192
C	ALA211
C	LYS213
C	TYR262
C	VAL263
C	MET265
C	PRO266
C	ASN267
C	GLY268
C	ARG273
C	LEU318
C	HOH615

---

site_id	AC6
Number of Residues	17
Details	BINDING SITE FOR RESIDUE T12 D 603

Chain	Residue
D	MET192
D	VAL200
D	ALA211
D	LYS213
D	TYR262
D	VAL263
D	MET265
D	PRO266
D	ASN267
D	GLY268
D	SER269
D	ASP272
D	ARG273
D	LEU318
D	HOH619
D	HOH666
D	HOH707

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ASP311
B	ASP311
C	ASP311
D	ASP311

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	MET192
B	MET192
C	MET192
D	MET192

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
A	LYS213
D	LYS213
D	LYS313
D	ASP329
A	LYS313
A	ASP329
B	LYS213
B	LYS313
B	ASP329
C	LYS213
C	LYS313
C	ASP329

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32

Chain	Residue	Details
A	THR342
B	THR342
C	THR342
D	THR342

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103, ECO:0000269|Ref.32

Chain	Residue	Details
A	TPO345
B	TPO345
C	TPO345
D	TPO345

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17161373, ECO:0000269|PubMed:17312103

Chain	Residue	Details
A	SEP346
B	SEP346
C	SEP346
D	SEP346

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP311
A	ALA315

---

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP311
B	LYS313
B	THR351

---

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP311
C	LYS313
C	THR351

---

site_id	CSA12
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP311
D	LYS313
D	THR351

---

site_id	CSA13
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASN316
A	ASP311
A	LYS313

---

site_id	CSA14
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASN316
B	ASP311
B	LYS313

---

site_id	CSA15
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASN316
C	ASP311
C	LYS313

---

site_id	CSA16
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASN316
D	ASP311
D	LYS313

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP311
B	ALA315

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP311
C	ALA315

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP311
D	ALA315

---

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP311
A	LYS313

---

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
B	ASP311
B	LYS313

---

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
C	ASP311
C	LYS313

---

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
D	ASP311
D	LYS313

---

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP311
A	LYS313
A	THR351

---