2JU4
NMR structure of the gamma subunit of cGMP phosphodiesterase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001750 | cellular_component | photoreceptor outer segment |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0004857 | molecular_function | enzyme inhibitor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0007601 | biological_process | visual perception |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030553 | molecular_function | cGMP binding |
| A | 0042622 | cellular_component | photoreceptor outer segment membrane |
| A | 0045742 | biological_process | positive regulation of epidermal growth factor receptor signaling pathway |
| A | 0045745 | biological_process | positive regulation of G protein-coupled receptor signaling pathway |
| A | 0047555 | molecular_function | 3',5'-cyclic-GMP phosphodiesterase activity |
| A | 0060090 | molecular_function | molecular adaptor activity |
| A | 0097381 | cellular_component | photoreceptor disc membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RCY A 110 |
| Chain | Residue |
| A | CYS10 |
| A | SER12 |
| A | ALA13 |
| A | THR14 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RCY A 121 |
| Chain | Residue |
| A | VAL16 |
| A | MET17 |
| A | GLY18 |
| A | CYS21 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE RCY A 130 |
| Chain | Residue |
| A | ARG33 |
| A | CYS30 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE RCY A 138 |
| Chain | Residue |
| A | ARG33 |
| A | CYS38 |
| A | CYS50 |
| A | GLY51 |
| A | ASP52 |
| A | PRO55 |
| A | RCY150 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE RCY A 150 |
| Chain | Residue |
| A | CYS38 |
| A | GLY49 |
| A | CYS50 |
| A | GLY51 |
| A | ASP52 |
| A | RCY138 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RCY A 160 |
| Chain | Residue |
| A | PRO55 |
| A | CYS60 |
| A | ILE64 |
| A | RCY168 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RCY A 168 |
| Chain | Residue |
| A | ILE64 |
| A | CYS68 |
| A | TRP70 |
| A | RCY160 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE RCY A 173 |
| Chain | Residue |
| A | PRO69 |
| A | CYS73 |
| A | RCY176 |
| A | RCY187 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE RCY A 176 |
| Chain | Residue |
| A | CYS76 |
| A | LEU78 |
| A | HIS79 |
| A | ALA82 |
| A | GLN83 |
| A | RCY173 |
| A | RCY187 |
| site_id | BC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE RCY A 187 |
| Chain | Residue |
| A | CYS87 |
| A | RCY173 |
| A | RCY176 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 11 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"3011376","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
