2JLR

Dengue virus 4 NS3 helicase in complex with AMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A1619

Chain	Residue
A	THR200
A	GLU285
A	ANP1620
A	HOH2308
A	HOH2309

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP A1620

Chain	Residue
A	LYS199
A	THR200
A	LYS201
A	GLU285
A	ASN329
A	ASN416
A	ARG418
A	ARG460
A	ARG463
A	MN1619
A	HOH2309
A	HOH2310
A	HOH2311
A	PRO195
A	GLY196
A	ALA197
A	GLY198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	156
Details	Domain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	167
Details	Domain: {"description":"Helicase C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Region: {"description":"Important for RNA-binding","evidences":[{"source":"UniProtKB","id":"P14340","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Motif: {"description":"DEAH box","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Involved in NS3 ATPase and RTPase activities","evidences":[{"source":"UniProtKB","id":"P14335","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine; by host","evidences":[{"source":"UniProtKB","id":"Q32ZE1","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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