2JLR

Dengue virus 4 NS3 helicase in complex with AMPPNP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MN A1619

Chain	Residue
A	THR200
A	GLU285
A	ANP1620
A	HOH2308
A	HOH2309

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ANP A1620

Chain	Residue
A	LYS199
A	THR200
A	LYS201
A	GLU285
A	ASN329
A	ASN416
A	ARG418
A	ARG460
A	ARG463
A	MN1619
A	HOH2309
A	HOH2310
A	HOH2311
A	PRO195
A	GLY196
A	ALA197
A	GLY198

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00541

Chain	Residue	Details
A	LEU193

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Involved in NS3 ATPase and RTPase activities => ECO:0000250|UniProtKB:P14335

Chain	Residue	Details
A	ARG457
A	ARG460

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:P29990

Chain	Residue	Details
A	LYS618

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; by host => ECO:0000250|UniProtKB:Q32ZE1

Chain	Residue	Details
A	LYS388

---