2JEV
Crystal structure of human spermine,spermidine acetyltransferase in complex with a bisubstrate analog (N1-acetylspermine-S-CoA).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001525 | biological_process | angiogenesis |
| A | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006596 | biological_process | polyamine biosynthetic process |
| A | 0008080 | molecular_function | N-acetyltransferase activity |
| A | 0009447 | biological_process | putrescine catabolic process |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0019809 | molecular_function | spermidine binding |
| A | 0032918 | biological_process | spermidine acetylation |
| A | 0042802 | molecular_function | identical protein binding |
| B | 0001525 | biological_process | angiogenesis |
| B | 0004145 | molecular_function | diamine N-acetyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006596 | biological_process | polyamine biosynthetic process |
| B | 0008080 | molecular_function | N-acetyltransferase activity |
| B | 0009447 | biological_process | putrescine catabolic process |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0019809 | molecular_function | spermidine binding |
| B | 0032918 | biological_process | spermidine acetylation |
| B | 0042802 | molecular_function | identical protein binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NHQ A1171 |
| Chain | Residue |
| A | TYR27 |
| A | GLY102 |
| A | PHE103 |
| A | GLY104 |
| A | ILE105 |
| A | GLY106 |
| A | SER107 |
| A | LEU128 |
| A | SER136 |
| A | PHE139 |
| A | TYR140 |
| A | GLU28 |
| A | HOH2021 |
| A | HOH2028 |
| B | ASP82 |
| B | TRP84 |
| B | TRP154 |
| B | NHQ1171 |
| A | GLU32 |
| A | GLU92 |
| A | ASP93 |
| A | PHE94 |
| A | PHE95 |
| A | VAL96 |
| A | ARG101 |
| site_id | AC2 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NHQ B1171 |
| Chain | Residue |
| A | ASP82 |
| A | TRP84 |
| A | TRP154 |
| A | NHQ1171 |
| B | TYR27 |
| B | GLU32 |
| B | GLU92 |
| B | ASP93 |
| B | PHE94 |
| B | PHE95 |
| B | VAL96 |
| B | ARG101 |
| B | GLY102 |
| B | PHE103 |
| B | GLY104 |
| B | ILE105 |
| B | GLY106 |
| B | SER107 |
| B | LEU128 |
| B | SER136 |
| B | PHE139 |
| B | TYR140 |
| B | HOH2031 |
| B | HOH2039 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P0A951","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17516632","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
