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2J0U

The crystal structure of eIF4AIII-Barentsz complex at 3.0 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A0000398biological_processmRNA splicing, via spliceosome
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003729molecular_functionmRNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006364biological_processrRNA processing
A0006397biological_processmRNA processing
A0006406biological_processmRNA export from nucleus
A0006417biological_processregulation of translation
A0008143molecular_functionpoly(A) binding
A0008306biological_processassociative learning
A0008380biological_processRNA splicing
A0010629biological_processnegative regulation of gene expression
A0016020cellular_componentmembrane
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017148biological_processnegative regulation of translation
A0030425cellular_componentdendrite
A0035145cellular_componentexon-exon junction complex
A0035368molecular_functionselenocysteine insertion sequence binding
A0035613molecular_functionRNA stem-loop binding
A0035640biological_processexploration behavior
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0045727biological_processpositive regulation of translation
A0048701biological_processembryonic cranial skeleton morphogenesis
A0051028biological_processmRNA transport
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0072715biological_processcellular response to selenite ion
A0090394biological_processnegative regulation of excitatory postsynaptic potential
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A1904570biological_processnegative regulation of selenocysteine incorporation
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
A1990904cellular_componentribonucleoprotein complex
A2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000166molecular_functionnucleotide binding
B0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000398biological_processmRNA splicing, via spliceosome
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003729molecular_functionmRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0006417biological_processregulation of translation
B0008143molecular_functionpoly(A) binding
B0008306biological_processassociative learning
B0008380biological_processRNA splicing
B0010629biological_processnegative regulation of gene expression
B0016020cellular_componentmembrane
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017148biological_processnegative regulation of translation
B0030425cellular_componentdendrite
B0035145cellular_componentexon-exon junction complex
B0035368molecular_functionselenocysteine insertion sequence binding
B0035613molecular_functionRNA stem-loop binding
B0035640biological_processexploration behavior
B0043021molecular_functionribonucleoprotein complex binding
B0043025cellular_componentneuronal cell body
B0045727biological_processpositive regulation of translation
B0048701biological_processembryonic cranial skeleton morphogenesis
B0051028biological_processmRNA transport
B0071006cellular_componentU2-type catalytic step 1 spliceosome
B0071013cellular_componentcatalytic step 2 spliceosome
B0072715biological_processcellular response to selenite ion
B0090394biological_processnegative regulation of excitatory postsynaptic potential
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
B1904570biological_processnegative regulation of selenocysteine incorporation
B1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B1990904cellular_componentribonucleoprotein complex
B2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
T0003723molecular_functionRNA binding
T0003729molecular_functionmRNA binding
T0006397biological_processmRNA processing
T0035145cellular_componentexon-exon junction complex
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
BVAL185-LEU193
AVAL185-LEU193

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
TSER148
BGLN66
BTHR86
BVAL343
BSER368

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60842
ChainResidueDetails
BGLY125

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
BPRO164

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60843
ChainResidueDetails
BGLU199

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
BMET297
BGLU322

site_idSWS_FT_FI6
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P60842
ChainResidueDetails
BLEU153
BGLY375

site_idSWS_FT_FI7
Number of Residues3
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BGLU315
BASN383

237735

PDB entries from 2025-06-18

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