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2IYF

The crystal structure of macrolide glycosyltransferases: A blueprint for antibiotic engineering

Functional Information from GO Data
ChainGOidnamespacecontents
A0008194molecular_functionUDP-glycosyltransferase activity
A0016757molecular_functionglycosyltransferase activity
A0016758molecular_functionhexosyltransferase activity
A0017000biological_processantibiotic biosynthetic process
A0046677biological_processresponse to antibiotic
B0008194molecular_functionUDP-glycosyltransferase activity
B0016757molecular_functionglycosyltransferase activity
B0016758molecular_functionhexosyltransferase activity
B0017000biological_processantibiotic biosynthetic process
B0046677biological_processresponse to antibiotic
Functional Information from PDB Data
site_idAC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ERY A1400
ChainResidue
AHIS19
AHOH2309
AHOH2310
AHOH2312
ATRP73
AASN80
AVAL81
AASN133
AALA182
ASER183
AASP329
AHOH2308

site_idAC2
Number of Residues18
DetailsBINDING SITE FOR RESIDUE UDP A1401
ChainResidue
AGLY239
ASER240
AALA241
AGLN267
ATRP289
AVAL290
AGLN292
AHIS305
AALA308
AGLY309
AGLY310
AGLU313
AHOH2214
AHOH2313
AHOH2314
AHOH2315
AHOH2316
AHOH2317

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ERY B1399
ChainResidue
BHIS19
BTRP73
BASN80
BPHE84
BILE111
BASN133
BLEU134
BTYR140
BALA182
BSER183
BHOH2108
BHOH2280
BHOH2281
BHOH2282

site_idAC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE UDP B1400
ChainResidue
BARG218
BGLY239
BSER240
BGLN267
BTRP289
BVAL290
BGLN292
BHIS305
BGLY307
BALA308
BGLY309
BGLY310
BGLU313
BHOH2182
BHOH2283
BHOH2287
BHOH2288

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B1401
ChainResidue
BTHR317
BHOH2212
BHOH2213
BHOH2215
BHOH2216

Functional Information from PROSITE/UniProt
site_idPS00375
Number of Residues42
DetailsUDPGT UDP-glycosyltransferases signature. WvpQlaILrqad..LFVTHAGagGsqeGLatat.PMiavPqavDQ
ChainResidueDetails
ATRP289-GLN330

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PDB entries from 2024-10-30

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