2IUW

Crystal structure of human ABH3 in complex with iron ion and 2- oxoglutarate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006281	biological_process	DNA repair
A	0006307	biological_process	DNA alkylation repair
A	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 500

Chain	Residue
A	HIS191
A	ASP193
A	HIS257
A	AKG700
A	HOH2150

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE A 501

Chain	Residue
A	ARG74
A	GLU75
A	HOH2006

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 502

Chain	Residue
A	SER83
A	GLY86
A	SER88
A	ASP254
A	SER81

---

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE AKG A 700

Chain	Residue
A	LED177
A	ASN179
A	TYR181
A	HIS191
A	ASP193
A	HIS257
A	VAL259
A	ARG269
A	ASN271
A	ARG275
A	FE500
A	HOH2150
A	HOH2225
A	HOH2226

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME A 800

Chain	Residue
A	CYS91
A	GLU248

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME A 801

Chain	Residue
A	THR85
A	GLU166
A	GLU167
A	CYS201
A	HOH2118

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME A 802

Chain	Residue
A	CYS110
A	PRO268
A	HOH2227

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME A 901

Chain	Residue
A	ASP189
A	ARG258
A	PRO260
A	LYS261
A	HOH2043

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q6NS38

Chain	Residue	Details
A	TRP115
A	TYR141
A	ASP194

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:16858410, ECO:0007744|PDB:2IUW

Chain	Residue	Details
A	ASN179
A	ARG269
A	ARG275

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00805, ECO:0000269|PubMed:16858410, ECO:0007744|PDB:2IUW

Chain	Residue	Details
A	HIS191
A	ASP193
A	HIS257

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: (4R)-5-oxoleucine; alternate => ECO:0000269|PubMed:16858410

Chain	Residue	Details
A	LED177

---