2IFV

Crystal structure of an active site mutant, C473D, of CDC25B phosphatase catalytic domain

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	1902751	biological_process	positive regulation of cell cycle G2/M phase transition

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 551

Chain	Residue
A	GLU446
A	ARG548
A	HOH559
A	HOH665

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 552

Chain	Residue
A	LYS394
A	SER476
A	LYS509

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	107
Details	Domain: {"description":"Rhodanese","evidences":[{"source":"PROSITE-ProRule","id":"PRU00173","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---