Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2IC5

Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0007015	biological_process	actin filament organization
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0008045	biological_process	motor neuron axon guidance
A	0008360	biological_process	regulation of cell shape
A	0010810	biological_process	regulation of cell-substrate adhesion
A	0012505	cellular_component	endomembrane system
A	0016055	biological_process	Wnt signaling pathway
A	0016601	biological_process	Rac protein signal transduction
A	0019901	molecular_function	protein kinase binding
A	0030027	cellular_component	lamellipodium
A	0030031	biological_process	cell projection assembly
A	0030036	biological_process	actin cytoskeleton organization
A	0030334	biological_process	regulation of cell migration
A	0030426	cellular_component	growth cone
A	0030865	biological_process	cortical cytoskeleton organization
A	0031410	cellular_component	cytoplasmic vesicle
A	0031941	cellular_component	filamentous actin
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
A	0035556	biological_process	intracellular signal transduction
A	0043005	cellular_component	neuron projection
A	0043020	cellular_component	NADPH oxidase complex
A	0043025	cellular_component	neuronal cell body
A	0045730	biological_process	respiratory burst
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0071944	cellular_component	cell periphery
A	0098794	cellular_component	postsynapse
A	0098974	biological_process	postsynaptic actin cytoskeleton organization
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0007015	biological_process	actin filament organization
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0008045	biological_process	motor neuron axon guidance
B	0008360	biological_process	regulation of cell shape
B	0010810	biological_process	regulation of cell-substrate adhesion
B	0012505	cellular_component	endomembrane system
B	0016055	biological_process	Wnt signaling pathway
B	0016601	biological_process	Rac protein signal transduction
B	0019901	molecular_function	protein kinase binding
B	0030027	cellular_component	lamellipodium
B	0030031	biological_process	cell projection assembly
B	0030036	biological_process	actin cytoskeleton organization
B	0030334	biological_process	regulation of cell migration
B	0030426	cellular_component	growth cone
B	0030865	biological_process	cortical cytoskeleton organization
B	0031410	cellular_component	cytoplasmic vesicle
B	0031941	cellular_component	filamentous actin
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
B	0035556	biological_process	intracellular signal transduction
B	0043005	cellular_component	neuron projection
B	0043020	cellular_component	NADPH oxidase complex
B	0043025	cellular_component	neuronal cell body
B	0045730	biological_process	respiratory burst
B	0048306	molecular_function	calcium-dependent protein binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0060326	biological_process	cell chemotaxis
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0098794	cellular_component	postsynapse
B	0098974	biological_process	postsynaptic actin cytoskeleton organization
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 301

Chain	Residue
B	THR17
B	GDP502
B	HOH503
B	HOH504
B	HOH505
B	HOH506

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	HOH603
A	HOH674
A	THR17
A	GNP501
A	HOH602

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 401

Chain	Residue
B	GLY12
B	LYS16
B	GLY60
B	GLN61
B	GDP502
B	HOH505

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 402

Chain	Residue
A	SER151

site_id	AC5
Number of Residues	27
Details	BINDING SITE FOR RESIDUE GNP A 501

Chain	Residue
A	GLY12
A	ALA13
A	VAL14
A	GLY15
A	LYS16
A	THR17
A	CYS18
A	PHE28
A	ILE33
A	GLY60
A	GLN61
A	LYS116
A	ASP118
A	LEU119
A	SER158
A	ALA159
A	LEU160
A	MG302
A	HOH602
A	HOH603
A	HOH614
A	HOH639
A	HOH656
A	HOH674
A	HOH696
A	HOH699
B	TYR64

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE GDP B 502

Chain	Residue
A	TYR64
B	ALA13
B	VAL14
B	GLY15
B	LYS16
B	THR17
B	CYS18
B	PHE28
B	ILE33
B	LYS116
B	ASP118
B	LEU119
B	SER158
B	ALA159
B	LEU160
B	MG301
B	CL401
B	HOH503
B	HOH505
B	HOH506
B	HOH511
B	HOH535
B	HOH569
B	HOH617

site_id	AC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE BTB A 601

Chain	Residue
A	TYR23
A	THR24
A	ASN26
A	ALA42
A	ASN43
A	LYS166
A	HOH642
A	HOH686
B	THR24
B	THR25
B	ASN26
B	HOH516
B	HOH531

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Human Rac3 in Complex with Gdp.","authors":["Debreczeni J.E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","von Delft F.","Doyle D.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"The Crystal Structure of the Human RAC3 in complex with GDP and Chloride.","authors":["Ugochukwu E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A.","von Delft F.","Doyle D."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.","authors":["Yang X.","Ugochukwu E.","Elkins J.","Doyle D."]}},{"source":"PDB","id":"2C2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IC5","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Knapp S.","Doyle D.A."]}},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Bunkoczi G.","Knapp S.","Doyle D."]}},{"source":"PDB","id":"2OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QME","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Human Rac3 in Complex with Gdp.","authors":["Debreczeni J.E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","von Delft F.","Doyle D.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"The Crystal Structure of the Human RAC3 in complex with GDP and Chloride.","authors":["Ugochukwu E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A.","von Delft F.","Doyle D."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.","authors":["Yang X.","Ugochukwu E.","Elkins J.","Doyle D."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Knapp S.","Doyle D.A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Bunkoczi G.","Knapp S.","Doyle D."]}},{"source":"PDB","id":"2C2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QME","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Human Rac3 in Complex with Gdp.","authors":["Debreczeni J.E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","von Delft F.","Doyle D.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A."]}},{"source":"PDB","id":"2C2H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24684802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	8
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Knapp S.","Doyle D.A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Bunkoczi G.","Knapp S.","Doyle D."]}},{"source":"PDB","id":"2OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QME","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN61

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN61

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)