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2IC5

Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.

Functional Information from GO Data
ChainGOidnamespacecontents
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007015biological_processactin filament organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0012505cellular_componentendomembrane system
A0014041biological_processregulation of neuron maturation
A0016055biological_processWnt signaling pathway
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019901molecular_functionprotein kinase binding
A0021894biological_processcerebral cortex GABAergic interneuron development
A0022604biological_processregulation of cell morphogenesis
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030036biological_processactin cytoskeleton organization
A0030426cellular_componentgrowth cone
A0030865biological_processcortical cytoskeleton organization
A0031175biological_processneuron projection development
A0031410cellular_componentcytoplasmic vesicle
A0031941cellular_componentfilamentous actin
A0032956biological_processregulation of actin cytoskeleton organization
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0035556biological_processintracellular signal transduction
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043020cellular_componentNADPH oxidase complex
A0043025cellular_componentneuronal cell body
A0043652biological_processengulfment of apoptotic cell
A0045730biological_processrespiratory burst
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048873biological_processhomeostasis of number of cells within a tissue
A0050885biological_processneuromuscular process controlling balance
A0050905biological_processneuromuscular process
A0051932biological_processsynaptic transmission, GABAergic
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0007015biological_processactin filament organization
B0007163biological_processestablishment or maintenance of cell polarity
B0007264biological_processsmall GTPase-mediated signal transduction
B0008045biological_processmotor neuron axon guidance
B0008360biological_processregulation of cell shape
B0012505cellular_componentendomembrane system
B0014041biological_processregulation of neuron maturation
B0016055biological_processWnt signaling pathway
B0016601biological_processRac protein signal transduction
B0016787molecular_functionhydrolase activity
B0019901molecular_functionprotein kinase binding
B0021894biological_processcerebral cortex GABAergic interneuron development
B0022604biological_processregulation of cell morphogenesis
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030036biological_processactin cytoskeleton organization
B0030426cellular_componentgrowth cone
B0030865biological_processcortical cytoskeleton organization
B0031175biological_processneuron projection development
B0031410cellular_componentcytoplasmic vesicle
B0031941cellular_componentfilamentous actin
B0032956biological_processregulation of actin cytoskeleton organization
B0033630biological_processpositive regulation of cell adhesion mediated by integrin
B0035556biological_processintracellular signal transduction
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043020cellular_componentNADPH oxidase complex
B0043025cellular_componentneuronal cell body
B0043652biological_processengulfment of apoptotic cell
B0045730biological_processrespiratory burst
B0048306molecular_functioncalcium-dependent protein binding
B0048471cellular_componentperinuclear region of cytoplasm
B0048873biological_processhomeostasis of number of cells within a tissue
B0050885biological_processneuromuscular process controlling balance
B0050905biological_processneuromuscular process
B0051932biological_processsynaptic transmission, GABAergic
B0060326biological_processcell chemotaxis
B0070062cellular_componentextracellular exosome
B0071944cellular_componentcell periphery
B0098974biological_processpostsynaptic actin cytoskeleton organization
B0098978cellular_componentglutamatergic synapse
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B1902622biological_processregulation of neutrophil migration
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG B 301
ChainResidue
BTHR17
BGDP502
BHOH503
BHOH504
BHOH505
BHOH506

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 302
ChainResidue
AHOH603
AHOH674
ATHR17
AGNP501
AHOH602

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL B 401
ChainResidue
BGLY12
BLYS16
BGLY60
BGLN61
BGDP502
BHOH505

site_idAC4
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 402
ChainResidue
ASER151

site_idAC5
Number of Residues27
DetailsBINDING SITE FOR RESIDUE GNP A 501
ChainResidue
AGLY12
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
APHE28
AILE33
AGLY60
AGLN61
ALYS116
AASP118
ALEU119
ASER158
AALA159
ALEU160
AMG302
AHOH602
AHOH603
AHOH614
AHOH639
AHOH656
AHOH674
AHOH696
AHOH699
BTYR64

site_idAC6
Number of Residues24
DetailsBINDING SITE FOR RESIDUE GDP B 502
ChainResidue
ATYR64
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BPHE28
BILE33
BLYS116
BASP118
BLEU119
BSER158
BALA159
BLEU160
BMG301
BCL401
BHOH503
BHOH505
BHOH506
BHOH511
BHOH535
BHOH569
BHOH617

site_idAC7
Number of Residues13
DetailsBINDING SITE FOR RESIDUE BTB A 601
ChainResidue
ATYR23
ATHR24
AASN26
AALA42
AASN43
ALYS166
AHOH642
AHOH686
BTHR24
BTHR25
BASN26
BHOH516
BHOH531

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY10
AASP57
ATHR115
BGLY10
BASP57
BTHR115

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR32

site_idSWS_FT_FI3
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24684802
ChainResidueDetails
ALYS166
BLYS166

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AGLN61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BGLN61

222926

PDB entries from 2024-07-24

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