2IAG

Crystal structure of human prostacyclin synthase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001516	biological_process	prostaglandin biosynthetic process
A	0004497	molecular_function	monooxygenase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005901	cellular_component	caveola
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006690	biological_process	icosanoid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0007566	biological_process	embryo implantation
A	0008116	molecular_function	prostaglandin-I synthase activity
A	0016020	cellular_component	membrane
A	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A	0016829	molecular_function	lyase activity
A	0016853	molecular_function	isomerase activity
A	0020037	molecular_function	heme binding
A	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
A	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
A	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
A	0045766	biological_process	positive regulation of angiogenesis
A	0046457	biological_process	prostanoid biosynthetic process
A	0046697	biological_process	decidualization
A	0046872	molecular_function	metal ion binding
A	0050728	biological_process	negative regulation of inflammatory response
A	0071347	biological_process	cellular response to interleukin-1
A	0071354	biological_process	cellular response to interleukin-6
A	0071456	biological_process	cellular response to hypoxia
A	0097190	biological_process	apoptotic signaling pathway
A	0106256	molecular_function	hydroperoxy icosatetraenoate dehydratase activity
A	1900119	biological_process	positive regulation of execution phase of apoptosis
B	0001516	biological_process	prostaglandin biosynthetic process
B	0004497	molecular_function	monooxygenase activity
B	0005506	molecular_function	iron ion binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005783	cellular_component	endoplasmic reticulum
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005901	cellular_component	caveola
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006690	biological_process	icosanoid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0007566	biological_process	embryo implantation
B	0008116	molecular_function	prostaglandin-I synthase activity
B	0016020	cellular_component	membrane
B	0016705	molecular_function	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B	0016829	molecular_function	lyase activity
B	0016853	molecular_function	isomerase activity
B	0020037	molecular_function	heme binding
B	0034355	biological_process	NAD+ biosynthetic process via the salvage pathway
B	0035360	biological_process	positive regulation of peroxisome proliferator activated receptor signaling pathway
B	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
B	0045766	biological_process	positive regulation of angiogenesis
B	0046457	biological_process	prostanoid biosynthetic process
B	0046697	biological_process	decidualization
B	0046872	molecular_function	metal ion binding
B	0050728	biological_process	negative regulation of inflammatory response
B	0071347	biological_process	cellular response to interleukin-1
B	0071354	biological_process	cellular response to interleukin-6
B	0071456	biological_process	cellular response to hypoxia
B	0097190	biological_process	apoptotic signaling pathway
B	0106256	molecular_function	hydroperoxy icosatetraenoate dehydratase activity
B	1900119	biological_process	positive regulation of execution phase of apoptosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE HEM A 600

Chain	Residue
A	MET124
A	CYS441
A	LEU442
A	GLY443
A	TYR446
A	ALA447
A	LEU485
A	HOH807
A	HOH812
A	GLN280
A	ALA283
A	THR284
A	ASN287
A	PRO433
A	TRP434
A	GLY435
A	ASN439

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE HEM B 600

Chain	Residue
B	LYS121
B	MET124
B	LEU128
B	ALA283
B	THR284
B	ASN287
B	MET288
B	PRO355
B	PRO433
B	TRP434
B	GLY435
B	ASN439
B	CYS441
B	LEU442
B	GLY443
B	ALA447
B	LEU485
B	HOH919
B	HOH921

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"F1RE08","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"17020766","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18032380","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2IAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B6H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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