2I82

Crystal structure of pseudouridine synthase RluA: indirect sequence readout through protein-induced RNA structure

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
A	0001522	biological_process	pseudouridine synthesis
A	0003723	molecular_function	RNA binding
A	0005829	cellular_component	cytosol
A	0006364	biological_process	rRNA processing
A	0006396	biological_process	RNA processing
A	0008033	biological_process	tRNA processing
A	0009451	biological_process	RNA modification
A	0009982	molecular_function	pseudouridine synthase activity
A	0016853	molecular_function	isomerase activity
A	0031118	biological_process	rRNA pseudouridine synthesis
A	0031119	biological_process	tRNA pseudouridine synthesis
A	0106029	molecular_function	tRNA pseudouridine synthase activity
A	0120159	molecular_function	rRNA pseudouridine synthase activity
A	0140098	molecular_function	catalytic activity, acting on RNA
A	0160142	molecular_function	23S rRNA pseudouridine(746) synthase activity
A	0160151	molecular_function	tRNA pseudouridine(32) synthase activity
B	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
B	0001522	biological_process	pseudouridine synthesis
B	0003723	molecular_function	RNA binding
B	0005829	cellular_component	cytosol
B	0006364	biological_process	rRNA processing
B	0006396	biological_process	RNA processing
B	0008033	biological_process	tRNA processing
B	0009451	biological_process	RNA modification
B	0009982	molecular_function	pseudouridine synthase activity
B	0016853	molecular_function	isomerase activity
B	0031118	biological_process	rRNA pseudouridine synthesis
B	0031119	biological_process	tRNA pseudouridine synthesis
B	0106029	molecular_function	tRNA pseudouridine synthase activity
B	0120159	molecular_function	rRNA pseudouridine synthase activity
B	0140098	molecular_function	catalytic activity, acting on RNA
B	0160142	molecular_function	23S rRNA pseudouridine(746) synthase activity
B	0160151	molecular_function	tRNA pseudouridine(32) synthase activity
C	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
C	0001522	biological_process	pseudouridine synthesis
C	0003723	molecular_function	RNA binding
C	0005829	cellular_component	cytosol
C	0006364	biological_process	rRNA processing
C	0006396	biological_process	RNA processing
C	0008033	biological_process	tRNA processing
C	0009451	biological_process	RNA modification
C	0009982	molecular_function	pseudouridine synthase activity
C	0016853	molecular_function	isomerase activity
C	0031118	biological_process	rRNA pseudouridine synthesis
C	0031119	biological_process	tRNA pseudouridine synthesis
C	0106029	molecular_function	tRNA pseudouridine synthase activity
C	0120159	molecular_function	rRNA pseudouridine synthase activity
C	0140098	molecular_function	catalytic activity, acting on RNA
C	0160142	molecular_function	23S rRNA pseudouridine(746) synthase activity
C	0160151	molecular_function	tRNA pseudouridine(32) synthase activity
D	0000455	biological_process	enzyme-directed rRNA pseudouridine synthesis
D	0001522	biological_process	pseudouridine synthesis
D	0003723	molecular_function	RNA binding
D	0005829	cellular_component	cytosol
D	0006364	biological_process	rRNA processing
D	0006396	biological_process	RNA processing
D	0008033	biological_process	tRNA processing
D	0009451	biological_process	RNA modification
D	0009982	molecular_function	pseudouridine synthase activity
D	0016853	molecular_function	isomerase activity
D	0031118	biological_process	rRNA pseudouridine synthesis
D	0031119	biological_process	tRNA pseudouridine synthesis
D	0106029	molecular_function	tRNA pseudouridine synthase activity
D	0120159	molecular_function	rRNA pseudouridine synthase activity
D	0140098	molecular_function	catalytic activity, acting on RNA
D	0160142	molecular_function	23S rRNA pseudouridine(746) synthase activity
D	0160151	molecular_function	tRNA pseudouridine(32) synthase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FOU E 3001

Chain	Residue
A	ARG62
A	ASP64
A	THR67
A	TYR96
A	LEU164
A	ARG165
A	LEU195
E	N1208

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site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FOU G 3003

Chain	Residue
C	THR667
C	TYR696
C	HIS762
C	GLN763
C	LEU764
C	LEU795
G	N1408
C	ASP664

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Functional Information from PROSITE/UniProt

site_id	PS01129
Number of Residues	15
Details	PSI_RLU Rlu family of pseudouridine synthase signature. VHRLDmaTSGVIVVA

Chain	Residue	Details
A	VAL60-ALA74

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"10383384","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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