2I0B

Crystal structure of the GluR6 ligand binding core ELKQ mutant dimer at 1.96 Angstroms Resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE SO4 B 601

Chain	Residue
B	PHE102
C	ARG228
C	THR232
C	HOH308
C	HOH335
B	LYS104
B	ARG228
B	ASP229
B	THR232
B	HOH701
C	GLU97
C	PHE102
C	LYS104

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU A 301

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	ALA91
A	ARG96
A	GLY141
A	ALA142
A	THR143
A	GLU191
A	HOH305
A	HOH311
A	HOH318
A	HOH330

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU B 302

Chain	Residue
B	TYR61
B	PRO89
B	LEU90
B	ALA91
B	ARG96
B	GLY141
B	ALA142
B	THR143
B	GLU191
B	HOH605
B	HOH619
B	HOH650
B	HOH672

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE GLU C 303

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	ALA91
C	ARG96
C	GLY141
C	ALA142
C	THR143
C	GLU191
C	HOH311
C	HOH313
C	HOH337
C	HOH357

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269|PubMed:15721240, ECO:0000269|PubMed:17115050, ECO:0007744|PDB:1S50, ECO:0007744|PDB:1S7Y, ECO:0007744|PDB:2I0B, ECO:0007744|PDB:2I0C

Chain	Residue	Details
A	PRO89
B	ALA142
B	THR143
B	GLU191
C	PRO89
C	ALA91
C	ARG96
C	ALA142
C	THR143
C	GLU191
A	ALA91
A	ARG96
A	ALA142
A	THR143
A	GLU191
B	PRO89
B	ALA91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15677325, ECO:0000269|PubMed:8163463

Chain	Residue	Details
A	ASN204
B	ASN204
C	ASN204

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