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2HXY

Crystal structure of human apo-eIF4AIII

Functional Information from GO Data
ChainGOidnamespacecontents
A0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
A0000398biological_processmRNA splicing, via spliceosome
A0003676molecular_functionnucleic acid binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003729molecular_functionmRNA binding
A0004386molecular_functionhelicase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005681cellular_componentspliceosomal complex
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006364biological_processrRNA processing
A0006397biological_processmRNA processing
A0006406biological_processmRNA export from nucleus
A0006417biological_processregulation of translation
A0008143molecular_functionpoly(A) binding
A0008306biological_processassociative learning
A0008380biological_processRNA splicing
A0010629biological_processnegative regulation of gene expression
A0014070biological_processresponse to organic cyclic compound
A0016020cellular_componentmembrane
A0016607cellular_componentnuclear speck
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0017148biological_processnegative regulation of translation
A0030425cellular_componentdendrite
A0035145cellular_componentexon-exon junction complex
A0035368molecular_functionselenocysteine insertion sequence binding
A0035613molecular_functionRNA stem-loop binding
A0035640biological_processexploration behavior
A0043021molecular_functionribonucleoprotein complex binding
A0043025cellular_componentneuronal cell body
A0045727biological_processpositive regulation of translation
A0048701biological_processembryonic cranial skeleton morphogenesis
A0051028biological_processmRNA transport
A0071006cellular_componentU2-type catalytic step 1 spliceosome
A0071013cellular_componentcatalytic step 2 spliceosome
A0072715biological_processcellular response to selenite ion
A0090394biological_processnegative regulation of excitatory postsynaptic potential
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A1904570biological_processnegative regulation of selenocysteine incorporation
A1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
A1990904cellular_componentribonucleoprotein complex
A2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
B0000398biological_processmRNA splicing, via spliceosome
B0003676molecular_functionnucleic acid binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003729molecular_functionmRNA binding
B0004386molecular_functionhelicase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005681cellular_componentspliceosomal complex
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006364biological_processrRNA processing
B0006397biological_processmRNA processing
B0006406biological_processmRNA export from nucleus
B0006417biological_processregulation of translation
B0008143molecular_functionpoly(A) binding
B0008306biological_processassociative learning
B0008380biological_processRNA splicing
B0010629biological_processnegative regulation of gene expression
B0014070biological_processresponse to organic cyclic compound
B0016020cellular_componentmembrane
B0016607cellular_componentnuclear speck
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0017148biological_processnegative regulation of translation
B0030425cellular_componentdendrite
B0035145cellular_componentexon-exon junction complex
B0035368molecular_functionselenocysteine insertion sequence binding
B0035613molecular_functionRNA stem-loop binding
B0035640biological_processexploration behavior
B0043021molecular_functionribonucleoprotein complex binding
B0043025cellular_componentneuronal cell body
B0045727biological_processpositive regulation of translation
B0048701biological_processembryonic cranial skeleton morphogenesis
B0051028biological_processmRNA transport
B0071006cellular_componentU2-type catalytic step 1 spliceosome
B0071013cellular_componentcatalytic step 2 spliceosome
B0072715biological_processcellular response to selenite ion
B0090394biological_processnegative regulation of excitatory postsynaptic potential
B0098794cellular_componentpostsynapse
B0098978cellular_componentglutamatergic synapse
B0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
B1904570biological_processnegative regulation of selenocysteine incorporation
B1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
B1990904cellular_componentribonucleoprotein complex
B2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
C0000398biological_processmRNA splicing, via spliceosome
C0003676molecular_functionnucleic acid binding
C0003723molecular_functionRNA binding
C0003724molecular_functionRNA helicase activity
C0003729molecular_functionmRNA binding
C0004386molecular_functionhelicase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005681cellular_componentspliceosomal complex
C0005730cellular_componentnucleolus
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006364biological_processrRNA processing
C0006397biological_processmRNA processing
C0006406biological_processmRNA export from nucleus
C0006417biological_processregulation of translation
C0008143molecular_functionpoly(A) binding
C0008306biological_processassociative learning
C0008380biological_processRNA splicing
C0010629biological_processnegative regulation of gene expression
C0014070biological_processresponse to organic cyclic compound
C0016020cellular_componentmembrane
C0016607cellular_componentnuclear speck
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0017148biological_processnegative regulation of translation
C0030425cellular_componentdendrite
C0035145cellular_componentexon-exon junction complex
C0035368molecular_functionselenocysteine insertion sequence binding
C0035613molecular_functionRNA stem-loop binding
C0035640biological_processexploration behavior
C0043021molecular_functionribonucleoprotein complex binding
C0043025cellular_componentneuronal cell body
C0045727biological_processpositive regulation of translation
C0048701biological_processembryonic cranial skeleton morphogenesis
C0051028biological_processmRNA transport
C0071006cellular_componentU2-type catalytic step 1 spliceosome
C0071013cellular_componentcatalytic step 2 spliceosome
C0072715biological_processcellular response to selenite ion
C0090394biological_processnegative regulation of excitatory postsynaptic potential
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
C1904570biological_processnegative regulation of selenocysteine incorporation
C1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
C1990904cellular_componentribonucleoprotein complex
C2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
D0000398biological_processmRNA splicing, via spliceosome
D0003676molecular_functionnucleic acid binding
D0003723molecular_functionRNA binding
D0003724molecular_functionRNA helicase activity
D0003729molecular_functionmRNA binding
D0004386molecular_functionhelicase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005681cellular_componentspliceosomal complex
D0005730cellular_componentnucleolus
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006364biological_processrRNA processing
D0006397biological_processmRNA processing
D0006406biological_processmRNA export from nucleus
D0006417biological_processregulation of translation
D0008143molecular_functionpoly(A) binding
D0008306biological_processassociative learning
D0008380biological_processRNA splicing
D0010629biological_processnegative regulation of gene expression
D0014070biological_processresponse to organic cyclic compound
D0016020cellular_componentmembrane
D0016607cellular_componentnuclear speck
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0017148biological_processnegative regulation of translation
D0030425cellular_componentdendrite
D0035145cellular_componentexon-exon junction complex
D0035368molecular_functionselenocysteine insertion sequence binding
D0035613molecular_functionRNA stem-loop binding
D0035640biological_processexploration behavior
D0043021molecular_functionribonucleoprotein complex binding
D0043025cellular_componentneuronal cell body
D0045727biological_processpositive regulation of translation
D0048701biological_processembryonic cranial skeleton morphogenesis
D0051028biological_processmRNA transport
D0071006cellular_componentU2-type catalytic step 1 spliceosome
D0071013cellular_componentcatalytic step 2 spliceosome
D0072715biological_processcellular response to selenite ion
D0090394biological_processnegative regulation of excitatory postsynaptic potential
D0098794cellular_componentpostsynapse
D0098978cellular_componentglutamatergic synapse
D0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
D1904570biological_processnegative regulation of selenocysteine incorporation
D1990416biological_processcellular response to brain-derived neurotrophic factor stimulus
D1990904cellular_componentribonucleoprotein complex
D2000622biological_processregulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Functional Information from PROSITE/UniProt
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. VLDEADEmL
ChainResidueDetails
AVAL185-LEU193

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000269|PubMed:16923391, ECO:0000269|PubMed:16931718, ECO:0000269|PubMed:19033377, ECO:0000269|PubMed:20479275, ECO:0007744|PDB:2HYI, ECO:0007744|PDB:2J0Q, ECO:0007744|PDB:2J0S, ECO:0007744|PDB:2XB2, ECO:0007744|PDB:3EX7
ChainResidueDetails
APRO61
BSER368
CPRO61
CGLN66
CTHR86
CVAL343
CSER368
DPRO61
DGLN66
DTHR86
DVAL343
AGLN66
DSER368
ATHR86
AVAL343
ASER368
BPRO61
BGLN66
BTHR86
BVAL343

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60842
ChainResidueDetails
AGLY125
BGLY125
CGLY125
DGLY125

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163
ChainResidueDetails
APRO164
BPRO164
CPRO164
DPRO164

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P60843
ChainResidueDetails
AGLU199
BGLU199
CGLU199
DGLU199

site_idSWS_FT_FI5
Number of Residues8
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
AMET297
AGLU322
BMET297
BGLU322
CMET297
CGLU322
DMET297
DGLU322

site_idSWS_FT_FI6
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P60842
ChainResidueDetails
ALEU153
AGLY375
BLEU153
BGLY375
CLEU153
CGLY375
DLEU153
DGLY375

site_idSWS_FT_FI7
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
DGLU315
DASN383
AGLU315
AASN383
BGLU315
BASN383
CGLU315
CASN383

223166

PDB entries from 2024-07-31

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