Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2HV8

Crystal structure of GTP-bound Rab11 in complex with FIP3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
C	0003924	molecular_function	GTPase activity
C	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 2ME B 2

Chain	Residue
B	ARG129
B	ARG132

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	SER25
A	THR43
A	GTP200
A	HOH2002
A	HOH2004

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 201

Chain	Residue
B	GTP200
B	HOH2005
B	HOH2010
B	SER25
B	THR43

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 201

Chain	Residue
C	SER25
C	THR43
C	GTP200
C	HOH2006
C	HOH2007

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 2001

Chain	Residue
A	LEU70
A	GLU71
A	ARG72
A	HOH2067
A	HOH2099
A	HOH2231

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 2002

Chain	Residue
C	LEU70
C	GLU71
C	ARG72
C	HOH2066
C	HOH2180

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 2003

Chain	Residue
B	LEU70
B	GLU71
B	ARG72
B	HOH2110
B	HOH2166

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 2004

Chain	Residue
A	ARG129
A	HIS130
B	LYS145
B	HOH2289

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 2005

Chain	Residue
A	ARG82
A	HOH2079
C	TYR73
C	ALA75
C	SER78
C	HOH2040
C	HOH2069
C	HOH2189

site_id	BC1
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GTP A 200

Chain	Residue
A	SER20
A	GLY21
A	VAL22
A	GLY23
A	LYS24
A	SER25
A	ASN26
A	PHE36
A	ASN37
A	LEU38
A	SER40
A	SER42
A	THR43
A	ALA68
A	GLY69
A	ASN124
A	LYS125
A	ASP127
A	LEU128
A	SER154
A	ALA155
A	LEU156
A	MG201
A	HOH2002
A	HOH2004
A	HOH2011
A	HOH2034
A	HOH2047
A	HOH2109
A	HOH2144
A	HOH2176

site_id	BC2
Number of Residues	31
Details	BINDING SITE FOR RESIDUE GTP B 200

Chain	Residue
B	HOH2005
B	HOH2010
B	HOH2043
B	HOH2063
B	HOH2070
B	HOH2172
B	HOH2184
B	HOH2220
B	SER20
B	GLY21
B	VAL22
B	GLY23
B	LYS24
B	SER25
B	ASN26
B	PHE36
B	ASN37
B	LEU38
B	SER40
B	SER42
B	THR43
B	ALA68
B	GLY69
B	ASN124
B	LYS125
B	ASP127
B	LEU128
B	SER154
B	ALA155
B	LEU156
B	MG201

site_id	BC3
Number of Residues	32
Details	BINDING SITE FOR RESIDUE GTP C 200

Chain	Residue
B	ASN116
B	HOH2193
C	SER20
C	GLY21
C	VAL22
C	GLY23
C	LYS24
C	SER25
C	ASN26
C	PHE36
C	ASN37
C	LEU38
C	SER40
C	SER42
C	THR43
C	ALA68
C	GLY69
C	ASN124
C	LYS125
C	ASP127
C	LEU128
C	SER154
C	ALA155
C	LEU156
C	MG201
C	HOH2006
C	HOH2007
C	HOH2025
C	HOH2065
C	HOH2068
C	HOH2097
C	HOH2181

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES B 1

Chain	Residue
B	THR43
B	ILE44
B	GLY45
B	GLU47
B	HOH2151
B	HOH2277
F	HOH765

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VVLiGDSGVGKsnL

Chain	Residue	Details
A	VAL14-LEU27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	Motif: {"description":"Switch 1","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	57
Details	Motif: {"description":"Switch 2","evidences":[{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15837192","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16034420","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OIX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HV8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16905101","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17007872","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17030804","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2D7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2GZH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	LEU70

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	LEU70

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	LEU70

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLY21

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLY21

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLY21

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)