2HUE

Structure of the H3-H4 chaperone Asf1 bound to histones H3 and H4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
B	0000786	cellular_component	nucleosome
B	0003677	molecular_function	DNA binding
B	0030527	molecular_function	structural constituent of chromatin
B	0046982	molecular_function	protein heterodimerization activity
C	0003677	molecular_function	DNA binding
C	0030527	molecular_function	structural constituent of chromatin
C	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 401

Chain	Residue
B	ARG63
B	HOH426
B	HOH434
B	HOH455
B	HOH467
B	HOH472
C	THR30
C	PRO32
C	ARG36

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 402

Chain	Residue
A	SER91
A	VAL92
A	GOL501
A	HOH568
B	ARG116
B	LYS122
B	HOH439
B	HOH474

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 403

Chain	Residue
A	ASP133
A	HIS134
A	HIS134
A	HOH558

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 501

Chain	Residue
A	VAL90
A	SER91
A	ASN114
A	ASN115
A	GLU116
A	HOH568
B	ALA114
B	LYS115
B	SO4402
B	HOH439

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 502

Chain	Residue
B	GLU73
B	ASP77
C	ARG23
C	ILE26
C	LYS59
C	HOH512

---

Functional Information from PROSITE/UniProt

site_id	PS00959
Number of Residues	9
Details	HISTONE_H3_2 Histone H3 signature 2. PFqRLVREI

Chain	Residue	Details
B	PRO66-ILE74

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
B	LYS64

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P84228

Chain	Residue	Details
B	LYS79
C	ARG92

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
B	THR80
B	THR107

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P84243

Chain	Residue	Details
B	SER86

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-glutaryllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
B	LYS115
C	ALA89

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
B	LYS122

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000250|UniProtKB:Q71DI3

Chain	Residue	Details
B	CYS110

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
C	PRO32

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62805

Chain	Residue	Details
C	ARG92

---