2HKJ

Topoisomerase VI-B bound to radicicol

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 471

Chain	Residue
A	ARG105
A	GLY106
A	HOH502
A	HOH553
A	HOH582
A	HOH658
A	HOH688

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DMS A 472

Chain	Residue
A	TYR345
A	GLN346
A	GLY347
A	HIS348
A	PRO309
A	ALA344

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site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE RDC A 501

Chain	Residue
A	LEU39
A	ASN42
A	ASP45
A	ALA46
A	ASP76
A	GLY80
A	ILE81
A	ALA89
A	PHE90
A	VAL112
A	THR170
A	VAL172
A	HOH506
A	HOH508
A	HOH560
A	HOH578

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:12505993, ECO:0000269|PubMed:15939019, ECO:0007744|PDB:1MX0, ECO:0007744|PDB:1Z59, ECO:0007744|PDB:1Z5A, ECO:0007744|PDB:1Z5B, ECO:0007744|PDB:1Z5C

Chain	Residue	Details
A	ASN42
A	ASP76
A	MET107

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12505993, ECO:0000269|PubMed:15939019, ECO:0007744|PDB:1MX0, ECO:0007744|PDB:1Z5A, ECO:0007744|PDB:1Z5B, ECO:0007744|PDB:1Z5C

Chain	Residue	Details
A	SER96

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12505993, ECO:0007744|PDB:1MX0

Chain	Residue	Details
A	LYS427

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