2HKA

Crystal structure of bovine NPC2 and cholesterol sulfate complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005764	cellular_component	lysosome
A	0005783	cellular_component	endoplasmic reticulum
A	0006629	biological_process	lipid metabolic process
A	0006869	biological_process	lipid transport
A	0008202	biological_process	steroid metabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0015485	molecular_function	cholesterol binding
A	0015918	biological_process	sterol transport
A	0030301	biological_process	cholesterol transport
A	0032367	biological_process	intracellular cholesterol transport
A	0032934	molecular_function	sterol binding
A	0033344	biological_process	cholesterol efflux
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005764	cellular_component	lysosome
B	0005783	cellular_component	endoplasmic reticulum
B	0006629	biological_process	lipid metabolic process
B	0006869	biological_process	lipid transport
B	0008202	biological_process	steroid metabolic process
B	0008203	biological_process	cholesterol metabolic process
B	0015485	molecular_function	cholesterol binding
B	0015918	biological_process	sterol transport
B	0030301	biological_process	cholesterol transport
B	0032367	biological_process	intracellular cholesterol transport
B	0032934	molecular_function	sterol binding
B	0033344	biological_process	cholesterol efflux
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005764	cellular_component	lysosome
C	0005783	cellular_component	endoplasmic reticulum
C	0006629	biological_process	lipid metabolic process
C	0006869	biological_process	lipid transport
C	0008202	biological_process	steroid metabolic process
C	0008203	biological_process	cholesterol metabolic process
C	0015485	molecular_function	cholesterol binding
C	0015918	biological_process	sterol transport
C	0030301	biological_process	cholesterol transport
C	0032367	biological_process	intracellular cholesterol transport
C	0032934	molecular_function	sterol binding
C	0033344	biological_process	cholesterol efflux

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9Z0J0","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12591954","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17573352","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NEP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HKA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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