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2HC2

Engineered protein tyrosine phosphatase beta catalytic domain

Functional Information from GO Data
ChainGOidnamespacecontents
A0004725molecular_functionprotein tyrosine phosphatase activity
A0006470biological_processprotein dephosphorylation
A0016311biological_processdephosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MG A 401
ChainResidue
AHOH1
AHOH2
AHOH3
AHOH4
AHOH5
AHOH6

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE NA A 402
ChainResidue
AHOH366
AGLY1872
ATHR1949

site_idAC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NA A 403
ChainResidue
ALEU1823
ATYR1824

Functional Information from PROSITE/UniProt
site_idPS00383
Number of Residues11
DetailsTYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGvgRTG
ChainResidueDetails
AVAL1902-GLY1912

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044, ECO:0000269|PubMed:17139078
ChainResidueDetails
AGLY1909

site_idSWS_FT_FI2
Number of Residues1
DetailsBINDING:
ChainResidueDetails
AGLU1875

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY1909
ATYR1953

Catalytic Information from CSA
site_idCSA1
Number of Residues6
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1910
AGLU1806
ACYS1904
AASP1870
ATHR1911
AHIS1903

site_idCSA2
Number of Residues4
DetailsAnnotated By Reference To The Literature 1ytw
ChainResidueDetails
AARG1910
ACYS1904
AASP1870
ATHR1911

227344

PDB entries from 2024-11-13

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