2H2H
The Structural basis of sirtuin substrate specificity
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017136 | molecular_function | NAD-dependent histone deacetylase activity |
| A | 0034979 | molecular_function | NAD-dependent protein lysine deacetylase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1001 |
| Chain | Residue |
| A | CYS124 |
| A | CYS127 |
| A | CYS148 |
| A | CYS151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| B | ARG10 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:16768447 |
| Chain | Residue | Details |
| B | THR12 | |
| A | GLY216 | |
| A | ASP231 | |
| A | VAL232 | |
| A | THR26 | |
| A | ARG34 | |
| A | GLN98 | |
| A | HIS116 | |
| A | SER189 | |
| A | SER190 | |
| A | ASN214 | |
| A | LEU215 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15780941, ECO:0007744|PDB:1YC5 |
| Chain | Residue | Details |
| A | PHE33 | |
| A | ILE100 | |
| A | ASP101 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15780941, ECO:0000269|PubMed:16768447, ECO:0000269|PubMed:16905097, ECO:0000269|PubMed:18786399, ECO:0000269|PubMed:19801667, ECO:0000269|PubMed:21080423, ECO:0007744|PDB:1YC5, ECO:0007744|PDB:2H2D, ECO:0007744|PDB:2H4F, ECO:0007744|PDB:3D4B, ECO:0007744|PDB:3JR3, ECO:0007744|PDB:3PDH |
| Chain | Residue | Details |
| A | CYS124 | |
| A | CYS127 | |
| A | CYS148 | |
| A | CYS151 |
