2GZ3
Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with NADP and aspartate-semialdehyde
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009088 | biological_process | L-threonine biosynthetic process |
| A | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| A | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009088 | biological_process | L-threonine biosynthetic process |
| B | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| B | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| C | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009088 | biological_process | L-threonine biosynthetic process |
| C | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| C | 0009097 | biological_process | isoleucine biosynthetic process |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0019877 | biological_process | diaminopimelate biosynthetic process |
| C | 0046983 | molecular_function | protein dimerization activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| C | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
| D | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0009088 | biological_process | L-threonine biosynthetic process |
| D | 0009089 | biological_process | L-lysine biosynthetic process via diaminopimelate |
| D | 0009097 | biological_process | isoleucine biosynthetic process |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0019877 | biological_process | diaminopimelate biosynthetic process |
| D | 0046983 | molecular_function | protein dimerization activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
| D | 0071266 | biological_process | 'de novo' L-methionine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAP A 367 |
| Chain | Residue |
| A | GLY9 |
| A | THR57 |
| A | SER71 |
| A | ALA72 |
| A | GLY73 |
| A | THR76 |
| A | ASN94 |
| A | THR95 |
| A | SER158 |
| A | GLY159 |
| A | GLY161 |
| A | THR11 |
| A | MET162 |
| A | ASN325 |
| A | LEU326 |
| A | GLY329 |
| A | ALA330 |
| A | AS2400 |
| A | HOH479 |
| A | HOH504 |
| A | HOH557 |
| A | GLY12 |
| A | ALA13 |
| A | VAL14 |
| A | ALA36 |
| A | SER37 |
| A | ARG39 |
| A | SER40 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE AS2 A 400 |
| Chain | Residue |
| A | ASN127 |
| A | CYS128 |
| A | GLN155 |
| A | GLY159 |
| A | ILE209 |
| A | GLU220 |
| A | ARG245 |
| A | HIS252 |
| A | NAP367 |
| A | HOH608 |
| site_id | AC3 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE NAP B 367 |
| Chain | Residue |
| B | GLY9 |
| B | THR11 |
| B | GLY12 |
| B | ALA13 |
| B | VAL14 |
| B | ALA36 |
| B | SER37 |
| B | SER40 |
| B | THR57 |
| B | SER71 |
| B | ALA72 |
| B | GLY73 |
| B | THR76 |
| B | ASN94 |
| B | SER158 |
| B | GLY159 |
| B | GLY161 |
| B | MET162 |
| B | ASN325 |
| B | LEU326 |
| B | AS2400 |
| B | HOH442 |
| B | HOH467 |
| B | HOH512 |
| D | LYS86 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AS2 B 400 |
| Chain | Residue |
| B | ASN127 |
| B | CYS128 |
| B | GLN155 |
| B | GLY159 |
| B | ILE209 |
| B | GLU220 |
| B | ARG245 |
| B | HIS252 |
| B | NAP367 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAP C 367 |
| Chain | Residue |
| A | LYS86 |
| C | GLY9 |
| C | THR11 |
| C | GLY12 |
| C | ALA13 |
| C | VAL14 |
| C | ALA36 |
| C | SER37 |
| C | ARG39 |
| C | SER40 |
| C | THR57 |
| C | SER71 |
| C | ALA72 |
| C | GLY73 |
| C | THR76 |
| C | ASN94 |
| C | THR95 |
| C | SER158 |
| C | GLY159 |
| C | GLY161 |
| C | MET162 |
| C | LEU326 |
| C | AS2400 |
| C | HOH500 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AS2 C 400 |
| Chain | Residue |
| C | GLY159 |
| C | ILE209 |
| C | GLU220 |
| C | ARG245 |
| C | HIS252 |
| C | NAP367 |
| C | ASN127 |
| C | CYS128 |
| C | GLN155 |
| site_id | AC7 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAP D 367 |
| Chain | Residue |
| D | GLY9 |
| D | THR11 |
| D | GLY12 |
| D | ALA13 |
| D | VAL14 |
| D | ALA36 |
| D | SER37 |
| D | ARG39 |
| D | SER40 |
| D | THR57 |
| D | SER71 |
| D | ALA72 |
| D | GLY73 |
| D | SER74 |
| D | THR76 |
| D | ASN94 |
| D | THR95 |
| D | SER158 |
| D | GLY159 |
| D | GLY161 |
| D | MET162 |
| D | ASN325 |
| D | LEU326 |
| D | GLY329 |
| D | ALA330 |
| D | AS2400 |
| D | HOH539 |
| D | HOH540 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE AS2 D 400 |
| Chain | Residue |
| D | ASN127 |
| D | CYS128 |
| D | GLN155 |
| D | GLY159 |
| D | ILE209 |
| D | GLU220 |
| D | ARG245 |
| D | HIS252 |
| D | NAP367 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| A | GLN155 | |
| A | HIS252 | |
| A | CYS128 |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| B | GLN155 | |
| B | HIS252 | |
| B | CYS128 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| C | GLN155 | |
| C | HIS252 | |
| C | CYS128 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| D | GLN155 | |
| D | HIS252 | |
| D | CYS128 |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| A | GLN155 | |
| A | CYS128 |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| B | GLN155 | |
| B | CYS128 |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| C | GLN155 | |
| C | CYS128 |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1brm |
| Chain | Residue | Details |
| D | GLN155 | |
| D | CYS128 |
