2FTW

Crystal structure of dihydropyrimidinase from dictyostelium discoideum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004157	molecular_function	dihydropyrimidinase activity
A	0005575	cellular_component	cellular_component
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006208	biological_process	pyrimidine nucleobase catabolic process
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0016810	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
A	0016812	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 522

Chain	Residue
A	HIS66
A	HIS68
A	KCX158
A	ASP325
A	HOH762

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 523

Chain	Residue
A	KCX158
A	HIS191
A	HIS247

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MLI A 524

Chain	Residue
A	TRP370
A	ASP472
A	GLY473
A	HOH797
A	TYR23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16517602","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Binding site: {"description":"via carbamate group","evidences":[{"source":"PubMed","id":"16517602","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9P903","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-carboxylysine","evidences":[{"source":"PubMed","id":"16517602","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2FTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1j79

Chain	Residue	Details
A	ASP325

---