2FSA
Crystal structure of PHD finger-linker-bromodomain fragment of human BPTF in the H3(1-15)K4ME2 bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0016589 | cellular_component | NURF complex |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0016589 | cellular_component | NURF complex |
| C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| C | 0016589 | cellular_component | NURF complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 501 |
| Chain | Residue |
| A | CYS11 |
| A | CYS13 |
| A | HIS34 |
| A | CYS37 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 502 |
| Chain | Residue |
| A | CYS26 |
| A | CYS29 |
| A | CYS53 |
| A | CYS56 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 503 |
| Chain | Residue |
| B | CYS13 |
| B | HIS34 |
| B | CYS37 |
| B | CYS11 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 504 |
| Chain | Residue |
| B | CYS26 |
| B | CYS29 |
| B | CYS53 |
| B | CYS56 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 505 |
| Chain | Residue |
| C | CYS11 |
| C | CYS13 |
| C | HIS34 |
| C | CYS37 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 506 |
| Chain | Residue |
| C | CYS26 |
| C | CYS29 |
| C | CYS53 |
| C | CYS56 |
Functional Information from PROSITE/UniProt
| site_id | PS00633 |
| Number of Residues | 58 |
| Details | BROMODOMAIN_1 Bromodomain signature. AwpFlepvDpndap..DYYgvIkepMdlatMeervqrry..Yekltefvadmtk.IfdNCryY |
| Chain | Residue | Details |
| A | ALA90-TYR147 |
| site_id | PS01186 |
| Number of Residues | 16 |
| Details | EGF_2 EGF-like domain signature 2. CiCktPYdeskfyigC |
| Chain | Residue | Details |
| A | CYS11-CYS26 |
| site_id | PS01359 |
| Number of Residues | 46 |
| Details | ZF_PHD_1 Zinc finger PHD-type signature. Ci.Cktpydeskfy...................................IgCdr..Cqnw.YHgrCvgilqseaelide................................YvCpqC |
| Chain | Residue | Details |
| A | CYS11-CYS56 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| P | ARG2 | |
| B | LYS8-THR59 | |
| C | LYS8-THR59 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
| Chain | Residue | Details |
| P | THR3 | |
| C | TYR17 | |
| C | TYR23 | |
| C | TRP32 | |
| A | TYR17 | |
| A | TYR23 | |
| A | TRP32 | |
| B | TYR10 | |
| B | TYR17 | |
| B | TYR23 | |
| B | TRP32 | |
| C | TYR10 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | MLY4 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| P | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| P | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| P | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| P | LYS9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| P | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| P | THR11 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| P | LYS14 |
