2FHJ
Crystal structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0015948 | biological_process | methanogenesis |
A | 0016740 | molecular_function | transferase activity |
A | 0016746 | molecular_function | acyltransferase activity |
A | 0019386 | biological_process | methanogenesis, from carbon dioxide |
A | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0015948 | biological_process | methanogenesis |
B | 0016740 | molecular_function | transferase activity |
B | 0016746 | molecular_function | acyltransferase activity |
B | 0019386 | biological_process | methanogenesis, from carbon dioxide |
B | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0015948 | biological_process | methanogenesis |
C | 0016740 | molecular_function | transferase activity |
C | 0016746 | molecular_function | acyltransferase activity |
C | 0019386 | biological_process | methanogenesis, from carbon dioxide |
C | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0015948 | biological_process | methanogenesis |
D | 0016740 | molecular_function | transferase activity |
D | 0016746 | molecular_function | acyltransferase activity |
D | 0019386 | biological_process | methanogenesis, from carbon dioxide |
D | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K C 303 |
Chain | Residue |
C | ASP57 |
C | ILE190 |
C | LYS191 |
C | VAL193 |
C | ALA196 |
C | HOH6062 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K C 306 |
Chain | Residue |
C | ALA103 |
C | HOH4004 |
C | VAL97 |
C | MET98 |
C | ALA100 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K C 309 |
Chain | Residue |
C | THR41 |
C | GLY44 |
C | ALA54 |
C | PRO199 |
C | HOH4452 |
D | GLU39 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K A 312 |
Chain | Residue |
A | GLU113 |
A | THR161 |
A | THR162 |
A | LEU251 |
A | HOH4272 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K A 313 |
Chain | Residue |
A | VAL97 |
A | MET98 |
A | ALA100 |
A | ALA103 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 315 |
Chain | Residue |
A | ASP57 |
A | ILE190 |
A | LYS191 |
A | VAL193 |
A | ALA196 |
A | HOH6009 |
site_id | AC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K A 316 |
Chain | Residue |
A | THR41 |
A | GLY44 |
A | ALA54 |
A | PRO199 |
B | GLU39 |
B | HOH8049 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 317 |
Chain | Residue |
A | GLU39 |
B | THR41 |
B | GLY44 |
B | ALA54 |
B | PRO199 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 319 |
Chain | Residue |
B | ASP57 |
B | ILE190 |
B | LYS191 |
B | VAL193 |
B | ALA196 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 322 |
Chain | Residue |
B | VAL97 |
B | MET98 |
B | ALA100 |
B | ALA103 |
B | HOH4455 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K D 500 |
Chain | Residue |
D | ASP57 |
D | ILE190 |
D | LYS191 |
D | VAL193 |
D | ALA196 |
D | HOH4253 |
site_id | BC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K D 501 |
Chain | Residue |
D | VAL97 |
D | MET98 |
D | ALA100 |
D | ALA103 |
D | HOH4109 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K D 502 |
Chain | Residue |
D | GLU113 |
D | THR161 |
D | THR162 |
D | LEU251 |
D | HOH4182 |
D | HOH4374 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE K D 503 |
Chain | Residue |
C | GLU39 |
D | THR41 |
D | GLY44 |
D | ALA54 |
D | PRO199 |
D | PE4921 |
site_id | BC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 504 |
Chain | Residue |
B | GLU113 |
B | THR161 |
B | THR162 |
B | LEU251 |
B | ASN252 |
site_id | BC7 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE K B 505 |
Chain | Residue |
B | HOH4291 |
site_id | BC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K C 506 |
Chain | Residue |
C | GLU113 |
C | THR161 |
C | THR162 |
C | LEU251 |
site_id | BC9 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE MFN A 900 |
Chain | Residue |
B | ALA221 |
B | GLU245 |
A | GLN95 |
A | MET98 |
A | TYR122 |
A | LYS123 |
A | PHE126 |
A | PHE127 |
B | SER46 |
B | PHE200 |
B | VAL205 |
B | SER207 |
B | ALA208 |
B | SER209 |
B | LEU219 |
site_id | CC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE MFN C 901 |
Chain | Residue |
C | LEU90 |
C | GLY94 |
C | GLN95 |
C | MET98 |
C | LYS123 |
C | PHE126 |
C | PHE127 |
D | ILE48 |
D | MET49 |
D | PHE200 |
D | VAL205 |
D | SER207 |
D | ALA208 |
D | SER209 |
D | GLU245 |
site_id | CC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE MFN A 902 |
Chain | Residue |
A | SER46 |
A | ILE48 |
A | MET49 |
A | PHE200 |
A | SER207 |
A | SER209 |
A | PHE218 |
A | LEU219 |
A | PRO220 |
A | H4Z905 |
B | GLN95 |
B | MET98 |
B | LYS123 |
B | PHE127 |
site_id | CC3 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE MFN D 903 |
Chain | Residue |
C | SER46 |
C | PHE200 |
C | VAL205 |
C | SER207 |
C | ALA208 |
C | SER209 |
C | GLU245 |
C | H4Z904 |
D | GLY94 |
D | GLN95 |
D | MET98 |
D | THR99 |
D | LYS123 |
D | PHE126 |
site_id | CC4 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE H4Z C 904 |
Chain | Residue |
C | ILE48 |
C | TYR170 |
C | SER209 |
C | LYS210 |
C | VAL211 |
C | ALA221 |
C | GLU245 |
C | PHE281 |
C | HOH8013 |
D | MFN903 |
site_id | CC5 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE H4Z A 905 |
Chain | Residue |
A | GLU14 |
A | PHE16 |
A | GLU53 |
A | ALA165 |
A | GLY166 |
A | TYR170 |
A | PRO199 |
A | SER209 |
A | LYS210 |
A | VAL211 |
A | ALA221 |
A | GLU245 |
A | VAL247 |
A | ASN249 |
A | PHE281 |
A | LEU285 |
A | MFN902 |
A | HOH8000 |
site_id | CC6 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE PE4 D 920 |
Chain | Residue |
C | LYS31 |
C | LYS38 |
D | LYS38 |
D | GLU184 |
D | LYS191 |
D | GLY202 |
D | PE4921 |
D | HOH6059 |
site_id | CC7 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE PE4 D 921 |
Chain | Residue |
C | ILE35 |
C | LYS38 |
C | GLU39 |
D | LYS38 |
D | THR41 |
D | GLY55 |
D | ILE56 |
D | LYS191 |
D | ALA198 |
D | GLY202 |
D | K503 |
D | PE4920 |
site_id | CC8 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE PE4 A 922 |
Chain | Residue |
A | PRO177 |
A | LEU180 |
A | GLN181 |
A | GLU184 |
A | HOH4119 |
A | HOH4160 |
A | HOH4321 |
B | TRP32 |
C | PRO177 |
C | LEU180 |
C | GLN181 |
C | GLU184 |
C | HOH4131 |
D | SER29 |
D | TRP32 |
site_id | CC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE PE3 C 3792 |
Chain | Residue |
B | HIS30 |
B | LYS31 |
B | TYR60 |
C | LYS191 |
C | HOH4057 |