2FHJ
Crystal structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| A | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016746 | molecular_function | acyltransferase activity |
| B | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| B | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016746 | molecular_function | acyltransferase activity |
| C | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| C | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0015948 | biological_process | methanogenesis |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016746 | molecular_function | acyltransferase activity |
| D | 0019386 | biological_process | methanogenesis, from carbon dioxide |
| D | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 303 |
| Chain | Residue |
| C | ASP57 |
| C | ILE190 |
| C | LYS191 |
| C | VAL193 |
| C | ALA196 |
| C | HOH6062 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K C 306 |
| Chain | Residue |
| C | ALA103 |
| C | HOH4004 |
| C | VAL97 |
| C | MET98 |
| C | ALA100 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 309 |
| Chain | Residue |
| C | THR41 |
| C | GLY44 |
| C | ALA54 |
| C | PRO199 |
| C | HOH4452 |
| D | GLU39 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 312 |
| Chain | Residue |
| A | GLU113 |
| A | THR161 |
| A | THR162 |
| A | LEU251 |
| A | HOH4272 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K A 313 |
| Chain | Residue |
| A | VAL97 |
| A | MET98 |
| A | ALA100 |
| A | ALA103 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 315 |
| Chain | Residue |
| A | ASP57 |
| A | ILE190 |
| A | LYS191 |
| A | VAL193 |
| A | ALA196 |
| A | HOH6009 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 316 |
| Chain | Residue |
| A | THR41 |
| A | GLY44 |
| A | ALA54 |
| A | PRO199 |
| B | GLU39 |
| B | HOH8049 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 317 |
| Chain | Residue |
| A | GLU39 |
| B | THR41 |
| B | GLY44 |
| B | ALA54 |
| B | PRO199 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 319 |
| Chain | Residue |
| B | ASP57 |
| B | ILE190 |
| B | LYS191 |
| B | VAL193 |
| B | ALA196 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 322 |
| Chain | Residue |
| B | VAL97 |
| B | MET98 |
| B | ALA100 |
| B | ALA103 |
| B | HOH4455 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 500 |
| Chain | Residue |
| D | ASP57 |
| D | ILE190 |
| D | LYS191 |
| D | VAL193 |
| D | ALA196 |
| D | HOH4253 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 501 |
| Chain | Residue |
| D | VAL97 |
| D | MET98 |
| D | ALA100 |
| D | ALA103 |
| D | HOH4109 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 502 |
| Chain | Residue |
| D | GLU113 |
| D | THR161 |
| D | THR162 |
| D | LEU251 |
| D | HOH4182 |
| D | HOH4374 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 503 |
| Chain | Residue |
| C | GLU39 |
| D | THR41 |
| D | GLY44 |
| D | ALA54 |
| D | PRO199 |
| D | PE4921 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 504 |
| Chain | Residue |
| B | GLU113 |
| B | THR161 |
| B | THR162 |
| B | LEU251 |
| B | ASN252 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE K B 505 |
| Chain | Residue |
| B | HOH4291 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE K C 506 |
| Chain | Residue |
| C | GLU113 |
| C | THR161 |
| C | THR162 |
| C | LEU251 |
| site_id | BC9 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MFN A 900 |
| Chain | Residue |
| B | ALA221 |
| B | GLU245 |
| A | GLN95 |
| A | MET98 |
| A | TYR122 |
| A | LYS123 |
| A | PHE126 |
| A | PHE127 |
| B | SER46 |
| B | PHE200 |
| B | VAL205 |
| B | SER207 |
| B | ALA208 |
| B | SER209 |
| B | LEU219 |
| site_id | CC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MFN C 901 |
| Chain | Residue |
| C | LEU90 |
| C | GLY94 |
| C | GLN95 |
| C | MET98 |
| C | LYS123 |
| C | PHE126 |
| C | PHE127 |
| D | ILE48 |
| D | MET49 |
| D | PHE200 |
| D | VAL205 |
| D | SER207 |
| D | ALA208 |
| D | SER209 |
| D | GLU245 |
| site_id | CC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MFN A 902 |
| Chain | Residue |
| A | SER46 |
| A | ILE48 |
| A | MET49 |
| A | PHE200 |
| A | SER207 |
| A | SER209 |
| A | PHE218 |
| A | LEU219 |
| A | PRO220 |
| A | H4Z905 |
| B | GLN95 |
| B | MET98 |
| B | LYS123 |
| B | PHE127 |
| site_id | CC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MFN D 903 |
| Chain | Residue |
| C | SER46 |
| C | PHE200 |
| C | VAL205 |
| C | SER207 |
| C | ALA208 |
| C | SER209 |
| C | GLU245 |
| C | H4Z904 |
| D | GLY94 |
| D | GLN95 |
| D | MET98 |
| D | THR99 |
| D | LYS123 |
| D | PHE126 |
| site_id | CC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE H4Z C 904 |
| Chain | Residue |
| C | ILE48 |
| C | TYR170 |
| C | SER209 |
| C | LYS210 |
| C | VAL211 |
| C | ALA221 |
| C | GLU245 |
| C | PHE281 |
| C | HOH8013 |
| D | MFN903 |
| site_id | CC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE H4Z A 905 |
| Chain | Residue |
| A | GLU14 |
| A | PHE16 |
| A | GLU53 |
| A | ALA165 |
| A | GLY166 |
| A | TYR170 |
| A | PRO199 |
| A | SER209 |
| A | LYS210 |
| A | VAL211 |
| A | ALA221 |
| A | GLU245 |
| A | VAL247 |
| A | ASN249 |
| A | PHE281 |
| A | LEU285 |
| A | MFN902 |
| A | HOH8000 |
| site_id | CC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PE4 D 920 |
| Chain | Residue |
| C | LYS31 |
| C | LYS38 |
| D | LYS38 |
| D | GLU184 |
| D | LYS191 |
| D | GLY202 |
| D | PE4921 |
| D | HOH6059 |
| site_id | CC7 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE PE4 D 921 |
| Chain | Residue |
| C | ILE35 |
| C | LYS38 |
| C | GLU39 |
| D | LYS38 |
| D | THR41 |
| D | GLY55 |
| D | ILE56 |
| D | LYS191 |
| D | ALA198 |
| D | GLY202 |
| D | K503 |
| D | PE4920 |
| site_id | CC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE PE4 A 922 |
| Chain | Residue |
| A | PRO177 |
| A | LEU180 |
| A | GLN181 |
| A | GLU184 |
| A | HOH4119 |
| A | HOH4160 |
| A | HOH4321 |
| B | TRP32 |
| C | PRO177 |
| C | LEU180 |
| C | GLN181 |
| C | GLU184 |
| C | HOH4131 |
| D | SER29 |
| D | TRP32 |
| site_id | CC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PE3 C 3792 |
| Chain | Residue |
| B | HIS30 |
| B | LYS31 |
| B | TYR60 |
| C | LYS191 |
| C | HOH4057 |
