2F8X

Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0000978	molecular_function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
C	0001228	molecular_function	DNA-binding transcription activator activity, RNA polymerase II-specific
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006357	biological_process	regulation of transcription by RNA polymerase II
M	0003713	molecular_function	transcription coactivator activity
M	0007219	biological_process	Notch signaling pathway
M	0007221	biological_process	positive regulation of transcription of Notch receptor target
M	0016607	cellular_component	nuclear speck
M	0045944	biological_process	positive regulation of transcription by RNA polymerase II

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
M	SER45

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: (3S)-3-hydroxyasparagine; by HIF1AN => ECO:0000250

Chain	Residue	Details
K	VAL2022

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