2F5Z
Crystal Structure of Human Dihydrolipoamide Dehydrogenase (E3) Complexed to the E3-Binding Domain of Human E3-Binding Protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001669 | cellular_component | acrosomal vesicle |
| A | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005929 | cellular_component | cilium |
| A | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| A | 0006099 | biological_process | tricarboxylic acid cycle |
| A | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| A | 0009083 | biological_process | branched-chain amino acid catabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031514 | cellular_component | motile cilium |
| A | 0043159 | cellular_component | acrosomal matrix |
| A | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| A | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| A | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| A | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| B | 0001669 | cellular_component | acrosomal vesicle |
| B | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005929 | cellular_component | cilium |
| B | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| B | 0009083 | biological_process | branched-chain amino acid catabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| B | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
| B | 0031514 | cellular_component | motile cilium |
| B | 0043159 | cellular_component | acrosomal matrix |
| B | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| B | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| B | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| B | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| B | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| C | 0001669 | cellular_component | acrosomal vesicle |
| C | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005929 | cellular_component | cilium |
| C | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| C | 0006099 | biological_process | tricarboxylic acid cycle |
| C | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| C | 0009083 | biological_process | branched-chain amino acid catabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| C | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| C | 0031410 | cellular_component | cytoplasmic vesicle |
| C | 0031514 | cellular_component | motile cilium |
| C | 0043159 | cellular_component | acrosomal matrix |
| C | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| C | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| C | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| C | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| C | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| D | 0001669 | cellular_component | acrosomal vesicle |
| D | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005654 | cellular_component | nucleoplasm |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005929 | cellular_component | cilium |
| D | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| D | 0006099 | biological_process | tricarboxylic acid cycle |
| D | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| D | 0009083 | biological_process | branched-chain amino acid catabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| D | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| D | 0031410 | cellular_component | cytoplasmic vesicle |
| D | 0031514 | cellular_component | motile cilium |
| D | 0043159 | cellular_component | acrosomal matrix |
| D | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| D | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| D | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| D | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| D | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| E | 0001669 | cellular_component | acrosomal vesicle |
| E | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005654 | cellular_component | nucleoplasm |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005739 | cellular_component | mitochondrion |
| E | 0005759 | cellular_component | mitochondrial matrix |
| E | 0005929 | cellular_component | cilium |
| E | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| E | 0006099 | biological_process | tricarboxylic acid cycle |
| E | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| E | 0009083 | biological_process | branched-chain amino acid catabolic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| E | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| E | 0031410 | cellular_component | cytoplasmic vesicle |
| E | 0031514 | cellular_component | motile cilium |
| E | 0043159 | cellular_component | acrosomal matrix |
| E | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| E | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| E | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| E | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| E | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| E | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| E | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| F | 0001669 | cellular_component | acrosomal vesicle |
| F | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005634 | cellular_component | nucleus |
| F | 0005654 | cellular_component | nucleoplasm |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005739 | cellular_component | mitochondrion |
| F | 0005759 | cellular_component | mitochondrial matrix |
| F | 0005929 | cellular_component | cilium |
| F | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| F | 0006099 | biological_process | tricarboxylic acid cycle |
| F | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| F | 0009083 | biological_process | branched-chain amino acid catabolic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| F | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| F | 0031410 | cellular_component | cytoplasmic vesicle |
| F | 0031514 | cellular_component | motile cilium |
| F | 0043159 | cellular_component | acrosomal matrix |
| F | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| F | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| F | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| F | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| F | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| F | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| F | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| G | 0001669 | cellular_component | acrosomal vesicle |
| G | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005654 | cellular_component | nucleoplasm |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005759 | cellular_component | mitochondrial matrix |
| G | 0005929 | cellular_component | cilium |
| G | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| G | 0006099 | biological_process | tricarboxylic acid cycle |
| G | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| G | 0009083 | biological_process | branched-chain amino acid catabolic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| G | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| G | 0031410 | cellular_component | cytoplasmic vesicle |
| G | 0031514 | cellular_component | motile cilium |
| G | 0043159 | cellular_component | acrosomal matrix |
| G | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| G | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| G | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| G | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| G | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| G | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| G | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| H | 0001669 | cellular_component | acrosomal vesicle |
| H | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005654 | cellular_component | nucleoplasm |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005739 | cellular_component | mitochondrion |
| H | 0005759 | cellular_component | mitochondrial matrix |
| H | 0005929 | cellular_component | cilium |
| H | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| H | 0006099 | biological_process | tricarboxylic acid cycle |
| H | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| H | 0009083 | biological_process | branched-chain amino acid catabolic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| H | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| H | 0031410 | cellular_component | cytoplasmic vesicle |
| H | 0031514 | cellular_component | motile cilium |
| H | 0043159 | cellular_component | acrosomal matrix |
| H | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| H | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| H | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| H | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| H | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| H | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| H | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| I | 0001669 | cellular_component | acrosomal vesicle |
| I | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| I | 0005515 | molecular_function | protein binding |
| I | 0005634 | cellular_component | nucleus |
| I | 0005654 | cellular_component | nucleoplasm |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0005739 | cellular_component | mitochondrion |
| I | 0005759 | cellular_component | mitochondrial matrix |
| I | 0005929 | cellular_component | cilium |
| I | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| I | 0006099 | biological_process | tricarboxylic acid cycle |
| I | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| I | 0009083 | biological_process | branched-chain amino acid catabolic process |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| I | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| I | 0031410 | cellular_component | cytoplasmic vesicle |
| I | 0031514 | cellular_component | motile cilium |
| I | 0043159 | cellular_component | acrosomal matrix |
| I | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| I | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| I | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| I | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| I | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| I | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| I | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| J | 0001669 | cellular_component | acrosomal vesicle |
| J | 0004148 | molecular_function | dihydrolipoyl dehydrogenase (NADH) activity |
| J | 0005515 | molecular_function | protein binding |
| J | 0005634 | cellular_component | nucleus |
| J | 0005654 | cellular_component | nucleoplasm |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0005739 | cellular_component | mitochondrion |
| J | 0005759 | cellular_component | mitochondrial matrix |
| J | 0005929 | cellular_component | cilium |
| J | 0006086 | biological_process | pyruvate decarboxylation to acetyl-CoA |
| J | 0006099 | biological_process | tricarboxylic acid cycle |
| J | 0006103 | biological_process | 2-oxoglutarate metabolic process |
| J | 0009083 | biological_process | branched-chain amino acid catabolic process |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| J | 0019474 | biological_process | L-lysine catabolic process to acetyl-CoA |
| J | 0031410 | cellular_component | cytoplasmic vesicle |
| J | 0031514 | cellular_component | motile cilium |
| J | 0043159 | cellular_component | acrosomal matrix |
| J | 0045252 | cellular_component | oxoglutarate dehydrogenase complex |
| J | 0045254 | cellular_component | pyruvate dehydrogenase complex |
| J | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| J | 0120551 | biological_process | 2-oxoglutarate decarboxylation to succinyl-CoA |
| J | 0120552 | biological_process | branched-chain alpha-keto acid decarboxylation to branched-chain acyl-CoA |
| J | 0160157 | cellular_component | branched-chain alpha-ketoacid dehydrogenase complex |
| J | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| K | 0016746 | molecular_function | acyltransferase activity |
| L | 0016746 | molecular_function | acyltransferase activity |
| M | 0016746 | molecular_function | acyltransferase activity |
| N | 0016746 | molecular_function | acyltransferase activity |
| O | 0016746 | molecular_function | acyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2482 |
| Chain | Residue |
| A | ARG299 |
| A | ARG301 |
| A | ALA323 |
| A | GLY324 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2490 |
| Chain | Residue |
| C | HOH2601 |
| C | ARG299 |
| C | ARG301 |
| C | ALA323 |
| C | GLY324 |
| C | HOH2594 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2483 |
| Chain | Residue |
| A | HIS64 |
| A | GLY68 |
| A | THR69 |
| A | HOH2498 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2491 |
| Chain | Residue |
| C | HIS64 |
| C | GLY68 |
| C | THR69 |
| C | ASP70 |
| C | HOH2543 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2484 |
| Chain | Residue |
| A | LEU210 |
| A | GLY211 |
| A | HIS212 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2492 |
| Chain | Residue |
| C | LEU210 |
| C | GLY211 |
| C | HIS212 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2485 |
| Chain | Residue |
| A | ASN286 |
| A | LEU287 |
| A | GLY288 |
| A | LEU289 |
| A | GLU290 |
| A | GLU291 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2493 |
| Chain | Residue |
| C | ASN286 |
| C | LEU287 |
| C | GLY288 |
| C | LEU289 |
| C | GLU290 |
| C | GLU291 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2486 |
| Chain | Residue |
| B | ARG299 |
| B | ARG301 |
| B | ALA323 |
| B | GLY324 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2494 |
| Chain | Residue |
| A | HOH2597 |
| D | ARG299 |
| D | ARG301 |
| D | ALA323 |
| D | GLY324 |
| D | HOH2571 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2487 |
| Chain | Residue |
| B | HIS64 |
| B | THR69 |
| B | HOH2491 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2495 |
| Chain | Residue |
| D | HIS64 |
| D | GLY68 |
| D | THR69 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2488 |
| Chain | Residue |
| B | GLY211 |
| B | HIS212 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2496 |
| Chain | Residue |
| D | LEU210 |
| D | GLY211 |
| D | HIS212 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2489 |
| Chain | Residue |
| B | THR284 |
| B | ASN286 |
| B | LEU287 |
| B | GLY288 |
| B | LEU289 |
| B | GLU290 |
| site_id | BC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 2497 |
| Chain | Residue |
| D | THR284 |
| D | ASN286 |
| D | LEU287 |
| D | GLY288 |
| D | LEU289 |
| D | GLU290 |
| D | HOH2657 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2498 |
| Chain | Residue |
| E | ARG299 |
| E | ARG301 |
| E | ALA323 |
| E | GLY324 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2499 |
| Chain | Residue |
| E | HIS64 |
| E | GLY68 |
| E | THR69 |
| E | ASP70 |
| E | HOH2564 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2500 |
| Chain | Residue |
| E | LEU210 |
| E | GLY211 |
| E | HIS212 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 E 2501 |
| Chain | Residue |
| E | THR284 |
| E | ASN286 |
| E | LEU287 |
| E | GLY288 |
| E | LEU289 |
| E | GLU290 |
| E | GLU291 |
| site_id | CC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2502 |
| Chain | Residue |
| F | ARG299 |
| F | ARG301 |
| F | ALA323 |
| F | GLY324 |
| F | HOH2717 |
| F | HOH2718 |
| H | HOH2698 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2503 |
| Chain | Residue |
| F | THR69 |
| F | HOH2507 |
| F | HOH2686 |
| F | HIS64 |
| F | GLY68 |
| site_id | CC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2504 |
| Chain | Residue |
| F | GLY211 |
| F | HIS212 |
| site_id | CC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 F 2505 |
| Chain | Residue |
| F | THR284 |
| F | ASN286 |
| F | LEU287 |
| F | GLY288 |
| F | LEU289 |
| F | GLU290 |
| F | HOH2681 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2506 |
| Chain | Residue |
| G | ARG299 |
| G | ARG301 |
| G | ALA323 |
| G | GLY324 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2507 |
| Chain | Residue |
| G | HIS64 |
| G | GLY68 |
| G | THR69 |
| G | HOH2521 |
| G | HOH2682 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2508 |
| Chain | Residue |
| G | LEU210 |
| G | GLY211 |
| G | HIS212 |
| site_id | DC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 G 2509 |
| Chain | Residue |
| G | THR284 |
| G | ASN286 |
| G | LEU287 |
| G | GLY288 |
| G | LEU289 |
| G | GLU290 |
| G | GLU291 |
| site_id | DC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 2510 |
| Chain | Residue |
| H | ARG299 |
| H | ARG301 |
| H | ALA323 |
| H | GLY324 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 2511 |
| Chain | Residue |
| H | HIS64 |
| H | GLY68 |
| H | THR69 |
| H | HOH2604 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 H 2512 |
| Chain | Residue |
| H | LEU210 |
| H | GLY211 |
| H | HIS212 |
| H | HOH2784 |
| site_id | DC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 H 2513 |
| Chain | Residue |
| H | THR284 |
| H | ASN286 |
| H | LEU287 |
| H | GLY288 |
| H | LEU289 |
| H | GLU290 |
| H | HOH2622 |
| H | HOH2736 |
| site_id | DC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 I 2514 |
| Chain | Residue |
| G | LYS253 |
| I | ARG299 |
| I | ARG301 |
| I | ALA323 |
| I | GLY324 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 I 2515 |
| Chain | Residue |
| I | LEU210 |
| I | GLY211 |
| I | HIS212 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 I 2516 |
| Chain | Residue |
| I | THR284 |
| I | ASN286 |
| I | LEU287 |
| I | GLY288 |
| I | LEU289 |
| I | GLU290 |
| site_id | DC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 J 2517 |
| Chain | Residue |
| B | HOH2497 |
| J | ARG299 |
| J | ARG301 |
| J | ALA323 |
| J | GLY324 |
| site_id | EC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 J 2518 |
| Chain | Residue |
| J | HIS64 |
| J | THR69 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 J 2519 |
| Chain | Residue |
| J | LEU210 |
| J | GLY211 |
| J | HIS212 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 J 2520 |
| Chain | Residue |
| J | THR284 |
| J | ASN286 |
| J | LEU287 |
| J | GLY288 |
| J | LEU289 |
| J | GLU290 |
| site_id | EC4 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD A 480 |
| Chain | Residue |
| A | ILE12 |
| A | GLY13 |
| A | GLY15 |
| A | PRO16 |
| A | GLY17 |
| A | GLU36 |
| A | LYS37 |
| A | ASN38 |
| A | GLY43 |
| A | THR44 |
| A | CYS45 |
| A | VAL48 |
| A | GLY49 |
| A | CYS50 |
| A | LYS54 |
| A | GLY117 |
| A | TYR118 |
| A | GLY119 |
| A | ALA147 |
| A | THR148 |
| A | GLY149 |
| A | SER150 |
| A | SER168 |
| A | ILE189 |
| A | ARG280 |
| A | PHE283 |
| A | GLY319 |
| A | ASP320 |
| A | MET326 |
| A | LEU327 |
| A | ALA328 |
| A | HIS329 |
| A | TYR359 |
| A | HOH2491 |
| A | HOH2502 |
| A | HOH2507 |
| A | HOH2525 |
| B | HIS452 |
| site_id | EC5 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD B 480 |
| Chain | Residue |
| A | HIS452 |
| B | ILE12 |
| B | GLY13 |
| B | GLY15 |
| B | PRO16 |
| B | GLY17 |
| B | GLU36 |
| B | LYS37 |
| B | ASN38 |
| B | GLY43 |
| B | THR44 |
| B | CYS45 |
| B | VAL48 |
| B | GLY49 |
| B | CYS50 |
| B | SER53 |
| B | LYS54 |
| B | GLY117 |
| B | TYR118 |
| B | GLY119 |
| B | ALA147 |
| B | THR148 |
| B | GLY149 |
| B | SER150 |
| B | SER168 |
| B | ILE189 |
| B | ARG280 |
| B | GLY319 |
| B | ASP320 |
| B | MET326 |
| B | LEU327 |
| B | ALA328 |
| B | HIS329 |
| B | ALA331 |
| B | TYR359 |
| B | HOH2496 |
| B | HOH2514 |
| B | HOH2545 |
| site_id | EC6 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE FAD C 480 |
| Chain | Residue |
| C | GLY13 |
| C | SER14 |
| C | GLY15 |
| C | PRO16 |
| C | GLY17 |
| C | GLU36 |
| C | LYS37 |
| C | ASN38 |
| C | GLY43 |
| C | THR44 |
| C | CYS45 |
| C | VAL48 |
| C | GLY49 |
| C | CYS50 |
| C | SER53 |
| C | LYS54 |
| C | GLY117 |
| C | TYR118 |
| C | GLY119 |
| C | ALA147 |
| C | THR148 |
| C | GLY149 |
| C | SER150 |
| C | ILE189 |
| C | ARG280 |
| C | PHE283 |
| C | GLY319 |
| C | ASP320 |
| C | MET326 |
| C | LEU327 |
| C | ALA328 |
| C | HIS329 |
| C | TYR359 |
| C | HOH2496 |
| C | HOH2497 |
| C | HOH2502 |
| C | HOH2524 |
| C | HOH2602 |
| D | HIS452 |
| site_id | EC7 |
| Number of Residues | 42 |
| Details | BINDING SITE FOR RESIDUE FAD D 480 |
| Chain | Residue |
| C | HIS452 |
| D | ILE12 |
| D | GLY13 |
| D | SER14 |
| D | GLY15 |
| D | PRO16 |
| D | GLY17 |
| D | GLU36 |
| D | LYS37 |
| D | ASN38 |
| D | GLY43 |
| D | THR44 |
| D | CYS45 |
| D | VAL48 |
| D | GLY49 |
| D | CYS50 |
| D | SER53 |
| D | LYS54 |
| D | GLY117 |
| D | TYR118 |
| D | GLY119 |
| D | ALA147 |
| D | THR148 |
| D | GLY149 |
| D | SER150 |
| D | SER168 |
| D | ILE189 |
| D | ARG280 |
| D | PHE283 |
| D | GLY319 |
| D | ASP320 |
| D | MET326 |
| D | LEU327 |
| D | ALA328 |
| D | HIS329 |
| D | ALA331 |
| D | TYR359 |
| D | HOH2500 |
| D | HOH2503 |
| D | HOH2557 |
| D | HOH2574 |
| D | HOH2654 |
| site_id | EC8 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD E 480 |
| Chain | Residue |
| E | ILE12 |
| E | GLY13 |
| E | SER14 |
| E | GLY15 |
| E | PRO16 |
| E | GLY17 |
| E | GLU36 |
| E | LYS37 |
| E | ASN38 |
| E | GLY43 |
| E | THR44 |
| E | CYS45 |
| E | GLY49 |
| E | CYS50 |
| E | SER53 |
| E | LYS54 |
| E | GLY117 |
| E | TYR118 |
| E | GLY119 |
| E | ALA147 |
| E | THR148 |
| E | GLY149 |
| E | SER150 |
| E | SER168 |
| E | ILE189 |
| E | ARG280 |
| E | GLY319 |
| E | ASP320 |
| E | MET326 |
| E | LEU327 |
| E | ALA328 |
| E | HIS329 |
| E | ALA331 |
| E | TYR359 |
| E | HOH2502 |
| E | HOH2505 |
| E | HOH2515 |
| E | HOH2522 |
| E | HOH2536 |
| E | HOH2600 |
| F | HIS452 |
| site_id | EC9 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE FAD F 480 |
| Chain | Residue |
| E | HIS452 |
| F | GLY13 |
| F | SER14 |
| F | GLY15 |
| F | PRO16 |
| F | GLY17 |
| F | ILE35 |
| F | GLU36 |
| F | LYS37 |
| F | ASN38 |
| F | GLY43 |
| F | THR44 |
| F | CYS45 |
| F | VAL48 |
| F | GLY49 |
| F | CYS50 |
| F | LYS54 |
| F | GLY117 |
| F | TYR118 |
| F | GLY119 |
| F | ALA147 |
| F | THR148 |
| F | GLY149 |
| F | SER150 |
| F | ILE189 |
| F | ARG280 |
| F | PHE283 |
| F | GLY319 |
| F | ASP320 |
| F | MET326 |
| F | LEU327 |
| F | ALA328 |
| F | HIS329 |
| F | TYR359 |
| F | HOH2512 |
| F | HOH2517 |
| F | HOH2532 |
| F | HOH2535 |
| F | HOH2650 |
| site_id | FC1 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD G 480 |
| Chain | Residue |
| G | ILE12 |
| G | GLY13 |
| G | GLY15 |
| G | PRO16 |
| G | GLY17 |
| G | GLU36 |
| G | LYS37 |
| G | ASN38 |
| G | GLY43 |
| G | THR44 |
| G | CYS45 |
| G | VAL48 |
| G | GLY49 |
| G | CYS50 |
| G | LYS54 |
| G | GLY117 |
| G | TYR118 |
| G | GLY119 |
| G | ALA147 |
| G | THR148 |
| G | GLY149 |
| G | SER150 |
| G | SER168 |
| G | ARG280 |
| G | PHE283 |
| G | GLY319 |
| G | ASP320 |
| G | MET326 |
| G | LEU327 |
| G | ALA328 |
| G | HIS329 |
| G | TYR359 |
| G | HOH2522 |
| G | HOH2524 |
| G | HOH2533 |
| G | HOH2544 |
| G | HOH2631 |
| H | HIS452 |
| site_id | FC2 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD H 480 |
| Chain | Residue |
| G | HIS452 |
| H | ILE12 |
| H | GLY13 |
| H | SER14 |
| H | GLY15 |
| H | PRO16 |
| H | GLY17 |
| H | GLU36 |
| H | LYS37 |
| H | ASN38 |
| H | GLY43 |
| H | THR44 |
| H | CYS45 |
| H | GLY49 |
| H | CYS50 |
| H | LYS54 |
| H | GLY117 |
| H | TYR118 |
| H | GLY119 |
| H | ALA147 |
| H | THR148 |
| H | GLY149 |
| H | SER150 |
| H | ARG280 |
| H | PHE283 |
| H | GLY319 |
| H | ASP320 |
| H | MET326 |
| H | LEU327 |
| H | ALA328 |
| H | HIS329 |
| H | TYR359 |
| H | HOH2515 |
| H | HOH2516 |
| H | HOH2517 |
| H | HOH2528 |
| H | HOH2545 |
| site_id | FC3 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD I 480 |
| Chain | Residue |
| I | ILE12 |
| I | GLY13 |
| I | SER14 |
| I | GLY15 |
| I | PRO16 |
| I | GLY17 |
| I | ILE35 |
| I | GLU36 |
| I | LYS37 |
| I | ASN38 |
| I | GLY43 |
| I | THR44 |
| I | CYS45 |
| I | GLY49 |
| I | CYS50 |
| I | SER53 |
| I | LYS54 |
| I | GLY117 |
| I | TYR118 |
| I | GLY119 |
| I | ALA147 |
| I | THR148 |
| I | GLY149 |
| I | SER150 |
| I | ILE189 |
| I | ARG280 |
| I | PHE283 |
| I | GLY319 |
| I | ASP320 |
| I | MET326 |
| I | LEU327 |
| I | ALA328 |
| I | HIS329 |
| I | TYR359 |
| I | HOH2532 |
| I | HOH2533 |
| I | HOH2562 |
| J | HIS452 |
| site_id | FC4 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE FAD J 480 |
| Chain | Residue |
| I | HIS452 |
| J | ILE12 |
| J | GLY13 |
| J | SER14 |
| J | GLY15 |
| J | PRO16 |
| J | GLY17 |
| J | GLU36 |
| J | LYS37 |
| J | ASN38 |
| J | GLY43 |
| J | THR44 |
| J | CYS45 |
| J | GLY49 |
| J | CYS50 |
| J | SER53 |
| J | LYS54 |
| J | GLY117 |
| J | TYR118 |
| J | GLY119 |
| J | ALA147 |
| J | THR148 |
| J | GLY149 |
| J | SER150 |
| J | ILE189 |
| J | ARG280 |
| J | PHE283 |
| J | LEU287 |
| J | GLY319 |
| J | ASP320 |
| J | MET326 |
| J | LEU327 |
| J | ALA328 |
| J | HIS329 |
| J | ALA331 |
| J | TYR359 |
| J | HOH2521 |
| J | HOH2523 |
| J | HOH2533 |
| J | HOH2562 |
| J | HOH2608 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCLnvGCIP |
| Chain | Residue | Details |
| A | GLY42-PRO52 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"UniProtKB","id":"P09624","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 270 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15946682","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Site: {"description":"Important for interaction with PDHX and activity of multienzyme pyruvate dehydrogenase complex","evidences":[{"source":"PubMed","id":"20385101","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 70 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 50 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q6P6R2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"O08749","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 15 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 10 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 185 |
| Details | Domain: {"description":"Peripheral subunit-binding (PSBD)","evidences":[{"source":"PROSITE-ProRule","id":"PRU01170","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | CYS45 | |
| A | CYS50 | |
| B | HIS452 | |
| B | GLU457 |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| J | CYS45 | |
| J | CYS50 | |
| I | HIS452 | |
| I | GLU457 |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| A | HIS452 | |
| A | GLU457 | |
| B | CYS45 | |
| B | CYS50 |
| site_id | CSA3 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| D | HIS452 | |
| D | GLU457 | |
| C | CYS45 | |
| C | CYS50 |
| site_id | CSA4 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| D | CYS45 | |
| D | CYS50 | |
| C | HIS452 | |
| C | GLU457 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| F | HIS452 | |
| F | GLU457 | |
| E | CYS45 | |
| E | CYS50 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| F | CYS45 | |
| F | CYS50 | |
| E | HIS452 | |
| E | GLU457 |
| site_id | CSA7 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| H | HIS452 | |
| H | GLU457 | |
| G | CYS45 | |
| G | CYS50 |
| site_id | CSA8 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| H | CYS45 | |
| H | CYS50 | |
| G | HIS452 | |
| G | GLU457 |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1get |
| Chain | Residue | Details |
| J | HIS452 | |
| J | GLU457 | |
| I | CYS45 | |
| I | CYS50 |
