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2E8A

Crystal structure of the human Hsp70 ATPase domain in complex with AMP-PNP

Functional Information from GO Data
ChainGOidnamespacecontents
A0005524molecular_functionATP binding
A0140662molecular_functionATP-dependent protein folding chaperone
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG A 501
ChainResidue
AASP10
ATYR15
AANP601
AHOH626

site_idAC2
Number of Residues31
DetailsBINDING SITE FOR RESIDUE ANP A 601
ChainResidue
AGLY201
AGLY202
AGLY203
ATHR204
AGLY230
AGLU268
ALYS271
AARG272
ASER275
AGLY338
AGLY339
ASER340
AARG342
AILE343
AASP366
AMG501
AHOH616
AHOH618
AHOH624
AHOH626
AHOH627
AHOH630
AHOH653
AHOH775
AHOH851
AHOH959
AASP10
AGLY12
ATHR13
ATHR14
ATYR15

Functional Information from PROSITE/UniProt
site_idPS00297
Number of Residues8
DetailsHSP70_1 Heat shock hsp70 proteins family signature 1. IDLGTTyS
ChainResidueDetails
AILE9-SER16

site_idPS00329
Number of Residues14
DetailsHSP70_2 Heat shock hsp70 proteins family signature 2. IFDLGGGTfdvSIL
ChainResidueDetails
AILE197-LEU210

site_idPS01036
Number of Residues15
DetailsHSP70_3 Heat shock hsp70 proteins family signature 3. LvLvGGsTRIPkVqK
ChainResidueDetails
ALEU334-LYS348

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues5
DetailsBINDING:
ChainResidueDetails
AGLY12
ALYS71
AGLY202
AGLU268
AGLY339

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330
ChainResidueDetails
AALA2

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:27708256
ChainResidueDetails
ALYS77

site_idSWS_FT_FI4
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS108
ALYS246
ALYS348

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1kaz
ChainResidueDetails
ALYS71

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PDB entries from 2024-07-24

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