2DSQ

Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005520	molecular_function	insulin-like growth factor binding
A	0005576	cellular_component	extracellular region
B	0005520	molecular_function	insulin-like growth factor binding
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0008083	molecular_function	growth factor activity
G	0005520	molecular_function	insulin-like growth factor binding
G	0005576	cellular_component	extracellular region
H	0005520	molecular_function	insulin-like growth factor binding
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00222
Number of Residues	16
Details	IGFBP_N_1 Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. GCGCCatCAlglgmpC

Chain	Residue	Details
B	GLY31-CYS46

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site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlrrLemyC

Chain	Residue	Details
I	CYS47-CYS61

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site_id	PS00484
Number of Residues	35
Details	THYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. YlpnCnkn.GfYhsrQcetsmdgeaglcWCVypwnG

Chain	Residue	Details
G	TYR177-GLY211

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Domain: {"description":"IGFBP N-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00653","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	40
Details	Region: {"description":"A"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	4
Details	Motif: {"description":"Cell attachment site","evidences":[{"source":"PubMed","id":"7504269","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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