2DSQ

Structural Basis for the Inhibition of Insulin-like Growth Factors by IGF Binding Proteins

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005520	molecular_function	insulin-like growth factor binding
A	0005576	cellular_component	extracellular region
B	0005520	molecular_function	insulin-like growth factor binding
B	0005576	cellular_component	extracellular region
C	0005179	molecular_function	hormone activity
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0008083	molecular_function	growth factor activity
G	0005520	molecular_function	insulin-like growth factor binding
G	0005576	cellular_component	extracellular region
H	0005520	molecular_function	insulin-like growth factor binding
H	0005576	cellular_component	extracellular region
I	0005179	molecular_function	hormone activity
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0008083	molecular_function	growth factor activity

Functional Information from PROSITE/UniProt

site_id	PS00222
Number of Residues	16
Details	IGFBP_N_1 Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. GCGCCatCAlglgmpC

Chain	Residue	Details
B	GLY31-CYS46

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site_id	PS00262
Number of Residues	15
Details	INSULIN Insulin family signature. CCFRsCDlrrLemyC

Chain	Residue	Details
I	CYS47-CYS61

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site_id	PS00484
Number of Residues	35
Details	THYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. YlpnCnkn.GfYhsrQcetsmdgeaglcWCVypwnG

Chain	Residue	Details
G	TYR177-GLY211

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
G	THR168
H	THR168

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:19765076, ECO:0000269|PubMed:26091039, ECO:0000269|PubMed:7678248

Chain	Residue	Details
G	SER169
H	SER169

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039

Chain	Residue	Details
G	SER174
G	SER217
H	SER174
H	SER217

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