2CO0
WDR5 and unmodified Histone H3 complex at 2.25 Angstrom
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000123 | cellular_component | histone acetyltransferase complex |
| A | 0001501 | biological_process | skeletal system development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| A | 0035097 | cellular_component | histone methyltransferase complex |
| A | 0042393 | molecular_function | histone binding |
| A | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| A | 0044545 | cellular_component | NSL complex |
| A | 0044665 | cellular_component | MLL1/2 complex |
| A | 0044666 | cellular_component | MLL3/4 complex |
| A | 0045722 | biological_process | positive regulation of gluconeogenesis |
| A | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0045995 | biological_process | regulation of embryonic development |
| A | 0048188 | cellular_component | Set1C/COMPASS complex |
| A | 0051302 | biological_process | regulation of cell division |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0071339 | cellular_component | MLL1 complex |
| A | 0072686 | cellular_component | mitotic spindle |
| A | 0140004 | molecular_function | histone H3Q5ser reader activity |
| A | 0140109 | molecular_function | histone H3K4me1 reader activity |
| A | 0140672 | cellular_component | ATAC complex |
| C | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| C | 0000123 | cellular_component | histone acetyltransferase complex |
| C | 0001501 | biological_process | skeletal system development |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0006094 | biological_process | gluconeogenesis |
| C | 0006325 | biological_process | chromatin organization |
| C | 0006355 | biological_process | regulation of DNA-templated transcription |
| C | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| C | 0035097 | cellular_component | histone methyltransferase complex |
| C | 0042393 | molecular_function | histone binding |
| C | 0042800 | molecular_function | histone H3K4 methyltransferase activity |
| C | 0044545 | cellular_component | NSL complex |
| C | 0044665 | cellular_component | MLL1/2 complex |
| C | 0044666 | cellular_component | MLL3/4 complex |
| C | 0045722 | biological_process | positive regulation of gluconeogenesis |
| C | 0045815 | biological_process | transcription initiation-coupled chromatin remodeling |
| C | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| C | 0045995 | biological_process | regulation of embryonic development |
| C | 0048188 | cellular_component | Set1C/COMPASS complex |
| C | 0051302 | biological_process | regulation of cell division |
| C | 0051726 | biological_process | regulation of cell cycle |
| C | 0071339 | cellular_component | MLL1 complex |
| C | 0072686 | cellular_component | mitotic spindle |
| C | 0140004 | molecular_function | histone H3Q5ser reader activity |
| C | 0140109 | molecular_function | histone H3K4me1 reader activity |
| C | 0140672 | cellular_component | ATAC complex |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsdDkTLKIWDV |
| Chain | Residue | Details |
| C | LEU102-VAL116 | |
| C | ILE144-VAL158 | |
| C | ILE186-THR200 | |
| C | ILE274-LEU288 | |
| A | LEU102-VAL116 | |
| A | ILE144-VAL158 | |
| A | ILE186-THR200 | |
| A | ILE274-LEU288 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | SITE: Important for interaction with histone H3 |
| Chain | Residue | Details |
| C | ASP107 | |
| C | PHE133 | |
| C | PHE263 | |
| C | GLU322 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| C | LYS112 | |
| D | THR3 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS27 | |
| D | LYS4 | |
| C | LYS46 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| Chain | Residue | Details |
| B | GLN5 | |
| D | GLN5 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| Chain | Residue | Details |
| B | THR6 | |
| D | THR6 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| Chain | Residue | Details |
| B | ARG8 | |
| D | ARG8 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| B | LYS9 | |
| D | LYS9 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| B | SER10 | |
| D | SER10 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by PKC and CHEK1 => ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:18066052, ECO:0000269|PubMed:18243098, ECO:0000269|PubMed:22901803 |
| Chain | Residue | Details |
| B | THR11 | |
| D | THR11 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435 |
| Chain | Residue | Details |
| B | LYS14 | |
| D | LYS14 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| C | GLY73 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| C | ASP242 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| A | GLY73 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1g72 |
| Chain | Residue | Details |
| A | ASP242 |
