2CL0

CRYSTAL STRUCTURE ANALYSIS OF A FLUORESCENT FORM OF H-RAS P21 IN COMPLEX WITH GppNHp

Functional Information from GO Data

Chain	GOid	namespace	contents
X	0003924	molecular_function	GTPase activity
X	0005525	molecular_function	GTP binding
X	0007165	biological_process	signal transduction
X	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG X 167

Chain	Residue
X	HOH2110
X	HOH2119

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG X 168

Chain	Residue
X	SER17
X	GNP200
X	HOH2034
X	HOH2067
X	HOH2161

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG X 169

Chain	Residue
X	HOH2113
X	HOH2121
X	HOH2122
X	HOH2123
X	ASP132
X	HOH2112

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG X 170

Chain	Residue
X	GLU63
X	GNP200
X	HOH2030
X	HOH2035
X	HOH2072
X	HOH2074

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG X 171

Chain	Residue
X	GLN165
X	HOH2041
X	HOH2132
X	HOH2155
X	HOH2156

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site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE TRS X 199

Chain	Residue
X	GLN25
X	ASP38
X	SER39
X	TYR40
X	HOH2159
X	HOH2160

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site_id	AC7
Number of Residues	34
Details	BINDING SITE FOR RESIDUE GNP X 200

Chain	Residue
X	GLY12
X	GLY13
X	VAL14
X	GLY15
X	LYS16
X	SER17
X	ALA18
X	PHE28
X	VAL29
X	ASP30
X	GLU31
X	ASP33
X	GLY60
X	GLU63
X	ASN116
X	LYS117
X	ASP119
X	LEU120
X	SER145
X	ALA146
X	LYS147
X	MG168
X	MG170
X	XY2332
X	HOH2027
X	HOH2030
X	HOH2034
X	HOH2035
X	HOH2067
X	HOH2072
X	HOH2073
X	HOH2161
X	HOH2165
X	HOH2166

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE XY2 X 332

Chain	Residue
X	GLU31
X	CYS32
X	GNP200
X	HOH2017

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	17
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
X	GLN61

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