2CG5
Structure of aminoadipate-semialdehyde dehydrogenase- phosphopantetheinyl transferase in complex with cytosolic acyl carrier protein and coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008897 | molecular_function | holo-[acyl-carrier-protein] synthase activity |
| A | 0009258 | biological_process | 10-formyltetrahydrofolate catabolic process |
| A | 0015939 | biological_process | pantothenate metabolic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019878 | biological_process | lysine biosynthetic process via aminoadipic acid |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051604 | biological_process | protein maturation |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0031177 | molecular_function | phosphopantetheine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A1301 |
| Chain | Residue |
| A | GLN51 |
| A | ARG74 |
| A | ARG78 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A1302 |
| Chain | Residue |
| A | GLY149 |
| B | HIS2133 |
| B | ARG2138 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A1303 |
| Chain | Residue |
| B | ARG2168 |
| A | HIS156 |
| A | ASP231 |
| A | HOH2021 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE COA A1300 |
| Chain | Residue |
| A | ARG57 |
| A | ARG96 |
| A | LYS99 |
| A | GLY100 |
| A | LYS101 |
| A | PRO102 |
| A | ASN118 |
| A | ILE119 |
| A | SER120 |
| A | HIS121 |
| A | ASP139 |
| A | GLU191 |
| A | LYS195 |
| A | GLY198 |
| A | LEU201 |
| B | ASP2155 |
| B | ALA2156 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:P12785 |
| Chain | Residue | Details |
| B | ALA2156 | |
| A | ARG96 | |
| A | ASN118 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | SER2198 | |
| A | GLU191 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:16964243, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| B | THR2204 |
