2C4R

Catalytic domain of E. coli RNase E

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0003676	molecular_function	nucleic acid binding
L	0003723	molecular_function	RNA binding
L	0004540	molecular_function	RNA nuclease activity
L	0006396	biological_process	RNA processing
L	0008995	molecular_function	ribonuclease E activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN L1512

Chain	Residue
L	CYS404
L	CYS407

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site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE MG L1511

Chain	Residue
R	U9
R	HOH2001
L	ASP303
L	ASP346
L	HOH2001
L	HOH2002
L	HOH2003
L	HOH2004
L	HOH2005

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Region: {"description":"Interaction with RNA 5'-terminal monophosphate"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	3
Details	Region: {"description":"Required for zinc-mediated homotetramerization and catalytic activity"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16237448","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15779893","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18682225","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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