2BIJ

Crystal structure of the human protein tyrosine phosphatase PTPN5 (STEP, striatum enriched enriched Phosphatase)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004725	molecular_function	protein tyrosine phosphatase activity
A	0006470	biological_process	protein dephosphorylation
A	0016311	biological_process	dephosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1538

Chain	Residue
A	TRP435
A	LYS439
A	ARG478
A	GLN520
A	HOH2094

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Functional Information from PROSITE/UniProt

site_id	PS00383
Number of Residues	11
Details	TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG

Chain	Residue	Details
A	VAL470-GLY480

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044

Chain	Residue	Details
A	GLY496

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	GLU461
A	GLN516

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	GLY496

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by MAPK => ECO:0000269|PubMed:21777200

Chain	Residue	Details
A	GLU268

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	6
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	THR479
A	CYS472
A	ARG478
A	GLU379
A	HIS471
A	ASP437

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	CYS472
A	ARG478

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1ytw

Chain	Residue	Details
A	ARG478
A	THR479
A	CYS472
A	ASP437

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