Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BD1

A possible role of the second calcium ion in interfacial binding: Atomic and medium resolution crystal structures of the quadruple mutant of phospholipase A2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002227	biological_process	innate immune response in mucosa
A	0004623	molecular_function	phospholipase A2 activity
A	0005102	molecular_function	signaling receptor binding
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0006644	biological_process	phospholipid metabolic process
A	0008284	biological_process	positive regulation of cell population proliferation
A	0009986	cellular_component	cell surface
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0019731	biological_process	antibacterial humoral response
A	0032052	molecular_function	bile acid binding
A	0046470	biological_process	phosphatidylcholine metabolic process
A	0046471	biological_process	phosphatidylglycerol metabolic process
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0048146	biological_process	positive regulation of fibroblast proliferation
A	0050482	biological_process	arachidonate secretion
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
A	1904635	biological_process	positive regulation of podocyte apoptotic process
B	0002227	biological_process	innate immune response in mucosa
B	0004623	molecular_function	phospholipase A2 activity
B	0005102	molecular_function	signaling receptor binding
B	0005509	molecular_function	calcium ion binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006629	biological_process	lipid metabolic process
B	0006633	biological_process	fatty acid biosynthetic process
B	0006644	biological_process	phospholipid metabolic process
B	0008284	biological_process	positive regulation of cell population proliferation
B	0009986	cellular_component	cell surface
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0019731	biological_process	antibacterial humoral response
B	0032052	molecular_function	bile acid binding
B	0046470	biological_process	phosphatidylcholine metabolic process
B	0046471	biological_process	phosphatidylglycerol metabolic process
B	0046872	molecular_function	metal ion binding
B	0047498	molecular_function	calcium-dependent phospholipase A2 activity
B	0048146	biological_process	positive regulation of fibroblast proliferation
B	0050482	biological_process	arachidonate secretion
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	1904635	biological_process	positive regulation of podocyte apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 847

Chain	Residue
A	TYR28
A	GLY30
A	GLY32
A	ASP49
A	HOH202
A	HOH208

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 848

Chain	Residue
A	HOH226
A	HOH238
A	HOH239
A	ASN71
A	ASN72
A	GLU92

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 849

Chain	Residue
B	TYR28
B	GLY30
B	GLY32
B	ASP49
B	HOH203
B	HOH206

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 850

Chain	Residue
B	ASN71
B	ASN72
B	GLU92
B	HOH245
B	HOH254
B	HOH261

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MPD A 723

Chain	Residue
A	PHE22
A	GLY30
A	LEU31
A	HIS48
A	HOH202

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MPD B 724

Chain	Residue
B	PHE22
B	GLY30
B	HOH203

Functional Information from PROSITE/UniProt

site_id	PS00118
Number of Residues	8
Details	PA2_HIS Phospholipase A2 histidine active site. CCQtHDnC

Chain	Residue	Details
A	CYS44-CYS51

site_id	PS00119
Number of Residues	11
Details	PA2_ASP Phospholipase A2 aspartic acid active site. ICNCDRNAaIC

Chain	Residue	Details
A	ILE95-CYS105

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000269\|PubMed:7464926

Chain	Residue	Details
A	HIS48
A	ASP99
B	HIS48
B	ASP99

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269\|PubMed:10089353, ECO:0000269\|PubMed:7265241, ECO:0000269\|PubMed:9115986, ECO:0007744\|PDB:1BP2, ECO:0007744\|PDB:1KVW, ECO:0007744\|PDB:1MKS

Chain	Residue	Details
A	TYR28
A	GLY30
A	GLY32
A	ASP49
B	TYR28
B	GLY30
B	GLY32
B	ASP49

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
A	HIS48
A	GLY30
A	ASP99

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1n29

Chain	Residue	Details
B	HIS48
B	GLY30
B	ASP99

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)