2B4Y
Crystal Structure of Human Sirtuin homolog 5
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
A | 0070403 | molecular_function | NAD+ binding |
B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
B | 0070403 | molecular_function | NAD+ binding |
C | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
C | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
C | 0070403 | molecular_function | NAD+ binding |
D | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
D | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
D | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 1001 |
Chain | Residue |
A | CYS166 |
A | CYS169 |
A | CYS207 |
A | CYS212 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 2001 |
Chain | Residue |
B | CYS166 |
B | CYS169 |
B | CYS207 |
B | CYS212 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 3001 |
Chain | Residue |
C | CYS169 |
C | CYS207 |
C | CYS212 |
C | CYS166 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN D 4001 |
Chain | Residue |
D | CYS166 |
D | CYS169 |
D | CYS207 |
D | CYS212 |
site_id | AC5 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE APR A 1002 |
Chain | Residue |
A | GLY58 |
A | ALA59 |
A | GLY60 |
A | ALA63 |
A | GLU64 |
A | GLN140 |
A | HIS158 |
A | GLY249 |
A | THR250 |
A | SER251 |
A | ASN275 |
A | THR276 |
A | GLU277 |
A | PRO292 |
A | CYS293 |
A | EPE1003 |
A | HOH1033 |
A | HOH1070 |
A | HOH1160 |
A | HOH1176 |
A | HOH1190 |
site_id | AC6 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE APR B 2002 |
Chain | Residue |
B | GLY58 |
B | ALA59 |
B | GLY60 |
B | GLU64 |
B | THR69 |
B | GLN140 |
B | HIS158 |
B | GLY249 |
B | THR250 |
B | SER251 |
B | ASN275 |
B | THR276 |
B | GLU277 |
B | CYS293 |
B | EPE2003 |
B | HOH2028 |
B | HOH2031 |
B | HOH2160 |
B | HOH2171 |
site_id | AC7 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE APR C 3002 |
Chain | Residue |
B | HOH2043 |
C | GLY58 |
C | ALA59 |
C | GLY60 |
C | ALA63 |
C | GLU64 |
C | THR69 |
C | PHE70 |
C | ARG71 |
C | GLN140 |
C | HIS158 |
C | GLY249 |
C | THR250 |
C | SER251 |
C | VAL254 |
C | ASN275 |
C | THR276 |
C | GLU277 |
C | PRO292 |
C | CYS293 |
C | EPE3003 |
C | HOH3005 |
C | HOH3067 |
C | HOH3082 |
C | HOH3145 |
site_id | AC8 |
Number of Residues | 23 |
Details | BINDING SITE FOR RESIDUE APR D 4002 |
Chain | Residue |
D | HOH4007 |
D | HOH4039 |
D | HOH4072 |
D | HOH4128 |
D | HOH4135 |
D | GLY58 |
D | ALA59 |
D | GLY60 |
D | GLU64 |
D | THR69 |
D | PHE70 |
D | GLN140 |
D | HIS158 |
D | GLY249 |
D | THR250 |
D | SER251 |
D | VAL254 |
D | ASN275 |
D | THR276 |
D | GLU277 |
D | PRO292 |
D | CYS293 |
D | EPE4003 |
site_id | AC9 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE EPE A 1003 |
Chain | Residue |
A | ALA82 |
A | ALA86 |
A | TYR102 |
A | ARG105 |
A | HIS158 |
A | VAL221 |
A | TRP222 |
A | PHE223 |
A | GLY224 |
A | GLU225 |
A | APR1002 |
A | HOH1186 |
site_id | BC1 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE EPE B 2003 |
Chain | Residue |
B | ALA82 |
B | ALA86 |
B | TYR102 |
B | ARG105 |
B | VAL221 |
B | TRP222 |
B | PHE223 |
B | APR2002 |
site_id | BC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE EPE C 3003 |
Chain | Residue |
C | PHE70 |
C | ALA82 |
C | ALA86 |
C | ARG105 |
C | HIS158 |
C | VAL221 |
C | PHE223 |
C | GLU225 |
C | LEU227 |
C | APR3002 |
C | HOH3144 |
C | HOH3147 |
D | SER168 |
D | CYS169 |
site_id | BC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE EPE D 4003 |
Chain | Residue |
C | SER168 |
C | CYS169 |
D | PHE70 |
D | ALA82 |
D | ALA86 |
D | ARG105 |
D | HIS158 |
D | VAL221 |
D | PHE223 |
D | GLU225 |
D | LEU227 |
D | TYR255 |
D | APR4002 |
D | HOH4125 |
D | HOH4149 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00236, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:29180469 |
Chain | Residue | Details |
A | HIS158 | |
B | HIS158 | |
C | HIS158 | |
D | HIS158 |
site_id | SWS_FT_FI2 |
Number of Residues | 20 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:22767592, ECO:0000269|Ref.19 |
Chain | Residue | Details |
A | GLY58 | |
B | CYS293 | |
C | GLY58 | |
C | GLN140 | |
C | GLY249 | |
C | ASN275 | |
C | CYS293 | |
D | GLY58 | |
D | GLN140 | |
D | GLY249 | |
D | ASN275 | |
A | GLN140 | |
D | CYS293 | |
A | GLY249 | |
A | ASN275 | |
A | CYS293 | |
B | GLY58 | |
B | GLN140 | |
B | GLY249 | |
B | ASN275 |
site_id | SWS_FT_FI3 |
Number of Residues | 24 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03160 |
Chain | Residue | Details |
A | TYR102 | |
B | CYS169 | |
B | CYS207 | |
B | CYS212 | |
C | TYR102 | |
C | ARG105 | |
C | CYS166 | |
C | CYS169 | |
C | CYS207 | |
C | CYS212 | |
D | TYR102 | |
A | ARG105 | |
D | ARG105 | |
D | CYS166 | |
D | CYS169 | |
D | CYS207 | |
D | CYS212 | |
A | CYS166 | |
A | CYS169 | |
A | CYS207 | |
A | CYS212 | |
B | TYR102 | |
B | ARG105 | |
B | CYS166 |