Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004198 | molecular_function | calcium-dependent cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | VAL99 |
| A | GLY101 |
| A | ASP106 |
| A | GLU185 |
| A | HOH403 |
| A | HOH406 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 402 |
| Chain | Residue |
| A | ASP331 |
| A | GLU333 |
| A | HOH414 |
| A | GLU302 |
| A | ASP309 |
| A | MET329 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 404 |
| Chain | Residue |
| B | VAL99 |
| B | GLY101 |
| B | ASP106 |
| B | GLU185 |
| B | HOH442 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 403 |
| Chain | Residue |
| B | GLU302 |
| B | ASP309 |
| B | MET329 |
| B | ASP331 |
| B | GLU333 |
| B | HOH420 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME A 400 |
| Chain | Residue |
| A | TRP116 |
| A | LEU247 |
| A | GLY249 |
| A | GLU349 |
| A | CYS351 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME B 400 |
| Chain | Residue |
| A | GLN287 |
| B | GLN109 |
| B | GLY113 |
| B | CYS115 |
| B | HIS272 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE BME B 401 |
| Chain | Residue |
| B | TRP116 |
| B | LEU247 |
| B | GLY249 |
| B | GLU349 |
| B | CYS351 |
| B | HOH503 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGaLGDCWLlAA |
| Chain | Residue | Details |
| A | GLN109-ALA120 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 598 |
| Details | Domain: {"description":"Calpain catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00239","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | HIS272 | |
| A | GLN109 | |
| A | ASN296 | |
| A | CYS115 | |
| site_id | CSA2 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| B | HIS272 | |
| B | GLN109 | |
| B | ASN296 | |
| B | CYS115 | |
| site_id | CSA3 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| A | HIS272 | |
| A | GLN109 | |
| A | TRP298 | |
| A | ASN296 | |
| A | CYS115 | |
| site_id | CSA4 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1kfu |
| Chain | Residue | Details |
| B | HIS272 | |
| B | GLN109 | |
| B | TRP298 | |
| B | ASN296 | |
| B | CYS115 | |
