2AG2
Crystal Structure Analysis of GM2-activator protein complexed with Phosphatidylcholine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001573 | biological_process | ganglioside metabolic process |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005319 | molecular_function | lipid transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0007611 | biological_process | learning or memory |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016004 | molecular_function | phospholipase activator activity |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019915 | biological_process | lipid storage |
| A | 0030290 | molecular_function | sphingolipid activator protein activity |
| A | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0050877 | biological_process | nervous system process |
| A | 0050885 | biological_process | neuromuscular process controlling balance |
| A | 0070062 | cellular_component | extracellular exosome |
| B | 0001573 | biological_process | ganglioside metabolic process |
| B | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| B | 0005319 | molecular_function | lipid transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005764 | cellular_component | lysosome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006665 | biological_process | sphingolipid metabolic process |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0006869 | biological_process | lipid transport |
| B | 0007611 | biological_process | learning or memory |
| B | 0008047 | molecular_function | enzyme activator activity |
| B | 0009313 | biological_process | oligosaccharide catabolic process |
| B | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| B | 0016004 | molecular_function | phospholipase activator activity |
| B | 0016323 | cellular_component | basolateral plasma membrane |
| B | 0016324 | cellular_component | apical plasma membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019915 | biological_process | lipid storage |
| B | 0030290 | molecular_function | sphingolipid activator protein activity |
| B | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| B | 0035578 | cellular_component | azurophil granule lumen |
| B | 0043202 | cellular_component | lysosomal lumen |
| B | 0046479 | biological_process | glycosphingolipid catabolic process |
| B | 0050877 | biological_process | nervous system process |
| B | 0050885 | biological_process | neuromuscular process controlling balance |
| B | 0070062 | cellular_component | extracellular exosome |
| C | 0001573 | biological_process | ganglioside metabolic process |
| C | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| C | 0005319 | molecular_function | lipid transporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005764 | cellular_component | lysosome |
| C | 0005829 | cellular_component | cytosol |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0006665 | biological_process | sphingolipid metabolic process |
| C | 0006689 | biological_process | ganglioside catabolic process |
| C | 0006869 | biological_process | lipid transport |
| C | 0007611 | biological_process | learning or memory |
| C | 0008047 | molecular_function | enzyme activator activity |
| C | 0009313 | biological_process | oligosaccharide catabolic process |
| C | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| C | 0016004 | molecular_function | phospholipase activator activity |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0016324 | cellular_component | apical plasma membrane |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0019915 | biological_process | lipid storage |
| C | 0030290 | molecular_function | sphingolipid activator protein activity |
| C | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| C | 0035578 | cellular_component | azurophil granule lumen |
| C | 0043202 | cellular_component | lysosomal lumen |
| C | 0046479 | biological_process | glycosphingolipid catabolic process |
| C | 0050877 | biological_process | nervous system process |
| C | 0050885 | biological_process | neuromuscular process controlling balance |
| C | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 801 |
| Chain | Residue |
| A | SER49 |
| A | PRO50 |
| A | LEU51 |
| A | HIS81 |
| A | CYS83 |
| C | HOH3701 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 802 |
| Chain | Residue |
| B | LEU51 |
| B | HIS81 |
| B | CYS83 |
| A | HOH2495 |
| B | SER49 |
| B | PRO50 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 803 |
| Chain | Residue |
| C | SER49 |
| C | LEU51 |
| C | HIS81 |
| C | CYS83 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EPE A 900 |
| Chain | Residue |
| A | SER6 |
| A | TRP7 |
| A | GLU12 |
| A | HOH2357 |
| A | HOH2432 |
| A | HOH2441 |
| A | HOH2469 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EPE C 901 |
| Chain | Residue |
| C | SER6 |
| C | TRP7 |
| C | ASP8 |
| C | GLU12 |
| C | HOH3767 |
| C | HOH3774 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE CH5 B 2341 |
| Chain | Residue |
| A | TRP133 |
| A | LEU134 |
| B | LEU57 |
| B | LYS59 |
| B | ILE68 |
| B | ILE74 |
| B | LEU128 |
| B | LEU130 |
| B | LEU134 |
| B | TYR139 |
| B | LEU161 |
| B | DAO1364 |
| B | IPA1509 |
| B | OLA3628 |
| B | HOH3802 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE CH5 C 2342 |
| Chain | Residue |
| A | GLY63 |
| B | LEU64 |
| C | TYR73 |
| C | PHE82 |
| C | MET88 |
| C | LEU89 |
| C | MYR3045 |
| C | HOH3820 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE LP3 B 2343 |
| Chain | Residue |
| B | ALA17 |
| B | VAL18 |
| B | ILE19 |
| B | GLY41 |
| B | VAL53 |
| B | PRO97 |
| B | PRO106 |
| B | PHE111 |
| B | TYR116 |
| B | SER143 |
| B | LEU145 |
| B | GLY153 |
| B | ILE155 |
| B | IPA1508 |
| B | MYR3046 |
| site_id | AC9 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE LP3 A 2344 |
| Chain | Residue |
| A | LEU24 |
| A | VAL39 |
| A | LEU57 |
| A | ILE68 |
| A | ILE74 |
| A | LEU100 |
| A | LEU130 |
| A | TYR139 |
| A | ILE155 |
| A | ILE157 |
| A | LEU161 |
| A | IPA1504 |
| A | LP32345 |
| A | HOH2478 |
| A | HOH2504 |
| A | HOH2516 |
| A | HOH2518 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE LP3 A 2345 |
| Chain | Residue |
| A | IPA1504 |
| A | LP32344 |
| A | HOH2528 |
| A | ALA17 |
| A | VAL18 |
| A | GLY41 |
| A | SER42 |
| A | LEU47 |
| A | VAL53 |
| A | LEU55 |
| A | PHE82 |
| A | PRO106 |
| A | TYR116 |
| A | SER143 |
| A | VAL144 |
| A | LEU145 |
| A | ILE155 |
| A | IPA1502 |
| site_id | BC2 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE LP3 C 2346 |
| Chain | Residue |
| C | ALA17 |
| C | VAL18 |
| C | ILE19 |
| C | GLY41 |
| C | SER42 |
| C | VAL53 |
| C | PRO106 |
| C | TYR116 |
| C | SER143 |
| C | VAL144 |
| C | LEU145 |
| C | GLY153 |
| C | ILE155 |
| C | IPA1510 |
| C | IPA1512 |
| C | HOH3773 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OLA B 3628 |
| Chain | Residue |
| B | ILE19 |
| B | LEU24 |
| B | LEU37 |
| B | VAL39 |
| B | GLY41 |
| B | TYR116 |
| B | DAO1364 |
| B | IPA1508 |
| B | CH52341 |
| B | HOH3802 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OLA C 3629 |
| Chain | Residue |
| C | LEU24 |
| C | VAL39 |
| C | TYR116 |
| C | ILE141 |
| C | ALA159 |
| C | IPA1511 |
| C | MYR3045 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MYR C 3045 |
| Chain | Residue |
| C | PHE123 |
| C | VAL125 |
| C | CH52342 |
| C | OLA3629 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MYR B 3046 |
| Chain | Residue |
| B | LEU55 |
| B | TYR73 |
| B | PHE79 |
| B | LP32343 |
| B | HOH3820 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DAO B 1364 |
| Chain | Residue |
| B | ILE74 |
| B | PHE123 |
| B | VAL125 |
| B | PRO126 |
| B | LEU128 |
| B | CH52341 |
| B | OLA3628 |
| B | HOH3791 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 1502 |
| Chain | Residue |
| A | PHE111 |
| A | LP32345 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 1504 |
| Chain | Residue |
| A | ILE157 |
| A | LP32344 |
| A | LP32345 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA B 1508 |
| Chain | Residue |
| B | LEU47 |
| B | PHE111 |
| B | LP32343 |
| B | OLA3628 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE IPA B 1509 |
| Chain | Residue |
| B | GLY75 |
| B | ILE141 |
| B | CH52341 |
| B | HOH3712 |
| site_id | CC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA C 1510 |
| Chain | Residue |
| C | LP32346 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA C 1511 |
| Chain | Residue |
| C | TRP133 |
| C | LEU134 |
| C | TYR139 |
| C | LEU161 |
| C | OLA3629 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA C 1512 |
| Chain | Residue |
| C | LP32346 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE IPA C 1513 |
| Chain | Residue |
| C | LEU118 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE IPA C 1514 |
| Chain | Residue |
| C | LEU55 |
| C | TYR73 |
| C | ILE74 |
| C | GLY75 |
| C | HOH3820 |
| site_id | CC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA B 1515 |
| Chain | Residue |
| B | CYS107 |
| B | PHE111 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine |
| Chain | Residue | Details |
| A | ASN34 | |
| B | ASN34 | |
| C | ASN34 |
