Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2AG2

Crystal Structure Analysis of GM2-activator protein complexed with Phosphatidylcholine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001573	biological_process	ganglioside metabolic process
A	0004563	molecular_function	beta-N-acetylhexosaminidase activity
A	0005319	molecular_function	lipid transporter activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005764	cellular_component	lysosome
A	0006629	biological_process	lipid metabolic process
A	0006665	biological_process	sphingolipid metabolic process
A	0006689	biological_process	ganglioside catabolic process
A	0006869	biological_process	lipid transport
A	0008047	molecular_function	enzyme activator activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0016004	molecular_function	phospholipase activator activity
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0030290	molecular_function	sphingolipid activator protein activity
A	0032428	molecular_function	beta-N-acetylgalactosaminidase activity
A	0035578	cellular_component	azurophil granule lumen
A	0043202	cellular_component	lysosomal lumen
A	0046479	biological_process	glycosphingolipid catabolic process
A	0070062	cellular_component	extracellular exosome
B	0001573	biological_process	ganglioside metabolic process
B	0004563	molecular_function	beta-N-acetylhexosaminidase activity
B	0005319	molecular_function	lipid transporter activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005764	cellular_component	lysosome
B	0006629	biological_process	lipid metabolic process
B	0006665	biological_process	sphingolipid metabolic process
B	0006689	biological_process	ganglioside catabolic process
B	0006869	biological_process	lipid transport
B	0008047	molecular_function	enzyme activator activity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0016004	molecular_function	phospholipase activator activity
B	0016323	cellular_component	basolateral plasma membrane
B	0016324	cellular_component	apical plasma membrane
B	0016787	molecular_function	hydrolase activity
B	0030290	molecular_function	sphingolipid activator protein activity
B	0032428	molecular_function	beta-N-acetylgalactosaminidase activity
B	0035578	cellular_component	azurophil granule lumen
B	0043202	cellular_component	lysosomal lumen
B	0046479	biological_process	glycosphingolipid catabolic process
B	0070062	cellular_component	extracellular exosome
C	0001573	biological_process	ganglioside metabolic process
C	0004563	molecular_function	beta-N-acetylhexosaminidase activity
C	0005319	molecular_function	lipid transporter activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005764	cellular_component	lysosome
C	0006629	biological_process	lipid metabolic process
C	0006665	biological_process	sphingolipid metabolic process
C	0006689	biological_process	ganglioside catabolic process
C	0006869	biological_process	lipid transport
C	0008047	molecular_function	enzyme activator activity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0016004	molecular_function	phospholipase activator activity
C	0016323	cellular_component	basolateral plasma membrane
C	0016324	cellular_component	apical plasma membrane
C	0016787	molecular_function	hydrolase activity
C	0030290	molecular_function	sphingolipid activator protein activity
C	0032428	molecular_function	beta-N-acetylgalactosaminidase activity
C	0035578	cellular_component	azurophil granule lumen
C	0043202	cellular_component	lysosomal lumen
C	0046479	biological_process	glycosphingolipid catabolic process
C	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 801

Chain	Residue
A	SER49
A	PRO50
A	LEU51
A	HIS81
A	CYS83
C	HOH3701

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 802

Chain	Residue
B	LEU51
B	HIS81
B	CYS83
A	HOH2495
B	SER49
B	PRO50

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 803

Chain	Residue
C	SER49
C	LEU51
C	HIS81
C	CYS83

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EPE A 900

Chain	Residue
A	SER6
A	TRP7
A	GLU12
A	HOH2357
A	HOH2432
A	HOH2441
A	HOH2469

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EPE C 901

Chain	Residue
C	SER6
C	TRP7
C	ASP8
C	GLU12
C	HOH3767
C	HOH3774

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CH5 B 2341

Chain	Residue
A	TRP133
A	LEU134
B	LEU57
B	LYS59
B	ILE68
B	ILE74
B	LEU128
B	LEU130
B	LEU134
B	TYR139
B	LEU161
B	DAO1364
B	IPA1509
B	OLA3628
B	HOH3802

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CH5 C 2342

Chain	Residue
A	GLY63
B	LEU64
C	TYR73
C	PHE82
C	MET88
C	LEU89
C	MYR3045
C	HOH3820

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE LP3 B 2343

Chain	Residue
B	ALA17
B	VAL18
B	ILE19
B	GLY41
B	VAL53
B	PRO97
B	PRO106
B	PHE111
B	TYR116
B	SER143
B	LEU145
B	GLY153
B	ILE155
B	IPA1508
B	MYR3046

site_id	AC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE LP3 A 2344

Chain	Residue
A	LEU24
A	VAL39
A	LEU57
A	ILE68
A	ILE74
A	LEU100
A	LEU130
A	TYR139
A	ILE155
A	ILE157
A	LEU161
A	IPA1504
A	LP32345
A	HOH2478
A	HOH2504
A	HOH2516
A	HOH2518

site_id	BC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE LP3 A 2345

Chain	Residue
A	IPA1504
A	LP32344
A	HOH2528
A	ALA17
A	VAL18
A	GLY41
A	SER42
A	LEU47
A	VAL53
A	LEU55
A	PHE82
A	PRO106
A	TYR116
A	SER143
A	VAL144
A	LEU145
A	ILE155
A	IPA1502

site_id	BC2
Number of Residues	16
Details	BINDING SITE FOR RESIDUE LP3 C 2346

Chain	Residue
C	ALA17
C	VAL18
C	ILE19
C	GLY41
C	SER42
C	VAL53
C	PRO106
C	TYR116
C	SER143
C	VAL144
C	LEU145
C	GLY153
C	ILE155
C	IPA1510
C	IPA1512
C	HOH3773

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OLA B 3628

Chain	Residue
B	ILE19
B	LEU24
B	LEU37
B	VAL39
B	GLY41
B	TYR116
B	DAO1364
B	IPA1508
B	CH52341
B	HOH3802

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLA C 3629

Chain	Residue
C	LEU24
C	VAL39
C	TYR116
C	ILE141
C	ALA159
C	IPA1511
C	MYR3045

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MYR C 3045

Chain	Residue
C	PHE123
C	VAL125
C	CH52342
C	OLA3629

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MYR B 3046

Chain	Residue
B	LEU55
B	TYR73
B	PHE79
B	LP32343
B	HOH3820

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DAO B 1364

Chain	Residue
B	ILE74
B	PHE123
B	VAL125
B	PRO126
B	LEU128
B	CH52341
B	OLA3628
B	HOH3791

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 1502

Chain	Residue
A	PHE111
A	LP32345

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA A 1504

Chain	Residue
A	ILE157
A	LP32344
A	LP32345

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IPA B 1508

Chain	Residue
B	LEU47
B	PHE111
B	LP32343
B	OLA3628

site_id	CC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IPA B 1509

Chain	Residue
B	GLY75
B	ILE141
B	CH52341
B	HOH3712

site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IPA C 1510

Chain	Residue
C	LP32346

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IPA C 1511

Chain	Residue
C	TRP133
C	LEU134
C	TYR139
C	LEU161
C	OLA3629

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IPA C 1512

Chain	Residue
C	LP32346

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IPA C 1513

Chain	Residue
C	LEU118

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE IPA C 1514

Chain	Residue
C	LEU55
C	TYR73
C	ILE74
C	GLY75
C	HOH3820

site_id	CC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA B 1515

Chain	Residue
B	CYS107
B	PHE111

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)