2AF9
Crystal Structure analysis of GM2-Activator protein complexed with phosphatidylcholine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001573 | biological_process | ganglioside metabolic process |
| A | 0004563 | molecular_function | beta-N-acetylhexosaminidase activity |
| A | 0005319 | molecular_function | lipid transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005764 | cellular_component | lysosome |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006665 | biological_process | sphingolipid metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0006869 | biological_process | lipid transport |
| A | 0008047 | molecular_function | enzyme activator activity |
| A | 0009898 | cellular_component | cytoplasmic side of plasma membrane |
| A | 0016004 | molecular_function | phospholipase activator activity |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030290 | molecular_function | sphingolipid activator protein activity |
| A | 0032428 | molecular_function | beta-N-acetylgalactosaminidase activity |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0046479 | biological_process | glycosphingolipid catabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE OLA A 3629 |
| Chain | Residue |
| A | ALA15 |
| A | HOH3732 |
| A | PHE109 |
| A | TYR114 |
| A | SER141 |
| A | LEU143 |
| A | GLY151 |
| A | CYS152 |
| A | ILE153 |
| A | DAO1364 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MYR A 3045 |
| Chain | Residue |
| A | ILE27 |
| A | VAL33 |
| A | LEU128 |
| A | THR133 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE DAO A 1364 |
| Chain | Residue |
| A | VAL51 |
| A | PHE80 |
| A | PHE109 |
| A | ILE139 |
| A | SER141 |
| A | ILE153 |
| A | ILE155 |
| A | OLA3629 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DAO A 1365 |
| Chain | Residue |
| A | LYS57 |
| A | LEU132 |
| A | TYR137 |
| A | ILE155 |
| A | ALA157 |
| A | LEU159 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE IPA A 1510 |
| Chain | Residue |
| A | IPA1511 |
| A | HOH3742 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE IPA A 1511 |
| Chain | Residue |
| A | LEU22 |
| A | ILE155 |
| A | IPA1510 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"} |
| Chain | Residue | Details |
