2AF9

Crystal Structure analysis of GM2-Activator protein complexed with phosphatidylcholine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001573	biological_process	ganglioside metabolic process
A	0004563	molecular_function	beta-N-acetylhexosaminidase activity
A	0005319	molecular_function	lipid transporter activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006665	biological_process	sphingolipid metabolic process
A	0006689	biological_process	ganglioside catabolic process
A	0006869	biological_process	lipid transport
A	0007611	biological_process	learning or memory
A	0008047	molecular_function	enzyme activator activity
A	0009313	biological_process	oligosaccharide catabolic process
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0016004	molecular_function	phospholipase activator activity
A	0016323	cellular_component	basolateral plasma membrane
A	0016324	cellular_component	apical plasma membrane
A	0016787	molecular_function	hydrolase activity
A	0019915	biological_process	lipid storage
A	0030290	molecular_function	sphingolipid activator protein activity
A	0032428	molecular_function	beta-N-acetylgalactosaminidase activity
A	0035578	cellular_component	azurophil granule lumen
A	0043202	cellular_component	lysosomal lumen
A	0046479	biological_process	glycosphingolipid catabolic process
A	0050877	biological_process	nervous system process
A	0050885	biological_process	neuromuscular process controlling balance
A	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE OLA A 3629

Chain	Residue
A	ALA15
A	HOH3732
A	PHE109
A	TYR114
A	SER141
A	LEU143
A	GLY151
A	CYS152
A	ILE153
A	DAO1364

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MYR A 3045

Chain	Residue
A	ILE27
A	VAL33
A	LEU128
A	THR133

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DAO A 1364

Chain	Residue
A	VAL51
A	PHE80
A	PHE109
A	ILE139
A	SER141
A	ILE153
A	ILE155
A	OLA3629

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DAO A 1365

Chain	Residue
A	LYS57
A	LEU132
A	TYR137
A	ILE155
A	ALA157
A	LEU159

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 1510

Chain	Residue
A	IPA1511
A	HOH3742

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA A 1511

Chain	Residue
A	LEU22
A	ILE155
A	IPA1510

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

Chain

Residue

Details

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