2A59
Structure of 6,7-Dimethyl-8-ribityllumazine synthase from Schizosaccharomyces pombe mutant W27Y with bound ligand 5-nitroso-6-ribitylamino-2,4(1H,3H)-pyrimidinedione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| A | 0004746 | molecular_function | riboflavin synthase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0009231 | biological_process | riboflavin biosynthetic process |
| A | 0009349 | cellular_component | riboflavin synthase complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 1902444 | molecular_function | riboflavin binding |
| B | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| B | 0004746 | molecular_function | riboflavin synthase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0009231 | biological_process | riboflavin biosynthetic process |
| B | 0009349 | cellular_component | riboflavin synthase complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 1902444 | molecular_function | riboflavin binding |
| C | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| C | 0004746 | molecular_function | riboflavin synthase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005758 | cellular_component | mitochondrial intermembrane space |
| C | 0009231 | biological_process | riboflavin biosynthetic process |
| C | 0009349 | cellular_component | riboflavin synthase complex |
| C | 0016740 | molecular_function | transferase activity |
| C | 1902444 | molecular_function | riboflavin binding |
| D | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| D | 0004746 | molecular_function | riboflavin synthase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005758 | cellular_component | mitochondrial intermembrane space |
| D | 0009231 | biological_process | riboflavin biosynthetic process |
| D | 0009349 | cellular_component | riboflavin synthase complex |
| D | 0016740 | molecular_function | transferase activity |
| D | 1902444 | molecular_function | riboflavin binding |
| E | 0000906 | molecular_function | 6,7-dimethyl-8-ribityllumazine synthase activity |
| E | 0004746 | molecular_function | riboflavin synthase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005634 | cellular_component | nucleus |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005758 | cellular_component | mitochondrial intermembrane space |
| E | 0009231 | biological_process | riboflavin biosynthetic process |
| E | 0009349 | cellular_component | riboflavin synthase complex |
| E | 0016740 | molecular_function | transferase activity |
| E | 1902444 | molecular_function | riboflavin binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 B 500 |
| Chain | Residue |
| A | ARG133 |
| B | GLY90 |
| B | SER91 |
| B | THR92 |
| B | HOH501 |
| B | HOH510 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 C 501 |
| Chain | Residue |
| C | THR92 |
| C | HOH502 |
| C | HOH513 |
| B | ARG133 |
| C | GLY90 |
| C | SER91 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 502 |
| Chain | Residue |
| C | ARG133 |
| D | GLY90 |
| D | SER91 |
| D | THR92 |
| D | HOH504 |
| D | HOH507 |
| D | HOH510 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 E 503 |
| Chain | Residue |
| D | ARG133 |
| E | GLY90 |
| E | SER91 |
| E | THR92 |
| E | HOH508 |
| E | HOH510 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PO4 A 504 |
| Chain | Residue |
| A | GLY90 |
| A | SER91 |
| A | THR92 |
| A | HOH505 |
| E | ARG133 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LMZ A 300 |
| Chain | Residue |
| A | TYR27 |
| A | ASN28 |
| A | GLY61 |
| A | SER62 |
| A | TRP63 |
| A | GLU64 |
| A | VAL86 |
| A | LEU87 |
| A | ILE88 |
| A | HIS94 |
| A | HOH506 |
| E | ILE118 |
| E | LEU119 |
| site_id | AC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LMZ B 301 |
| Chain | Residue |
| A | ILE118 |
| A | LEU119 |
| B | TYR27 |
| B | ASN28 |
| B | GLY61 |
| B | SER62 |
| B | TRP63 |
| B | GLU64 |
| B | VAL86 |
| B | LEU87 |
| B | ILE88 |
| B | HIS94 |
| B | HOH503 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE LMZ C 302 |
| Chain | Residue |
| B | ILE118 |
| B | LEU119 |
| C | TYR27 |
| C | ASN28 |
| C | GLY61 |
| C | SER62 |
| C | TRP63 |
| C | GLU64 |
| C | VAL86 |
| C | LEU87 |
| C | ILE88 |
| C | HIS94 |
| C | HOH504 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE LMZ D 303 |
| Chain | Residue |
| C | ILE118 |
| C | LEU119 |
| D | TYR27 |
| D | ASN28 |
| D | GLY61 |
| D | SER62 |
| D | TRP63 |
| D | GLU64 |
| D | VAL86 |
| D | LEU87 |
| D | ILE88 |
| D | HIS94 |
| D | HOH506 |
| D | HOH508 |
| site_id | BC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE LMZ E 304 |
| Chain | Residue |
| D | ILE118 |
| D | LEU119 |
| E | TYR27 |
| E | ASN28 |
| E | GLY61 |
| E | SER62 |
| E | TRP63 |
| E | GLU64 |
| E | VAL86 |
| E | LEU87 |
| E | ILE88 |
| E | HIS94 |
| E | HOH506 |
| E | HOH509 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton donor => ECO:0000255 |
| Chain | Residue | Details |
| A | HIS94 | |
| B | HIS94 | |
| C | HIS94 | |
| D | HIS94 | |
| E | HIS94 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | TYR27 | |
| C | SER62 | |
| C | VAL86 | |
| C | LEU119 | |
| D | TYR27 | |
| D | SER62 | |
| D | VAL86 | |
| D | LEU119 | |
| E | TYR27 | |
| E | SER62 | |
| E | VAL86 | |
| A | SER62 | |
| E | LEU119 | |
| A | VAL86 | |
| A | LEU119 | |
| B | TYR27 | |
| B | SER62 | |
| B | VAL86 | |
| B | LEU119 | |
| C | TYR27 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | BINDING: BINDING => ECO:0000305 |
| Chain | Residue | Details |
| A | SER91 | |
| E | ARG133 | |
| A | ARG133 | |
| B | SER91 | |
| B | ARG133 | |
| C | SER91 | |
| C | ARG133 | |
| D | SER91 | |
| D | ARG133 | |
| E | SER91 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| A | HIS94 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| B | HIS94 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| C | HIS94 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| D | HIS94 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1rvv |
| Chain | Residue | Details |
| E | HIS94 |
