2A1U

Crystal structure of the human ETF E165betaA mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0009055	molecular_function	electron transfer activity
A	0009063	biological_process	amino acid catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0022904	biological_process	respiratory electron transport chain
A	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A	0045251	cellular_component	electron transfer flavoprotein complex
A	0050660	molecular_function	flavin adenine dinucleotide binding
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0009055	molecular_function	electron transfer activity
B	0009063	biological_process	amino acid catabolic process
B	0022904	biological_process	respiratory electron transport chain
B	0033539	biological_process	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B	0045251	cellular_component	electron transfer flavoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	27
Details	BINDING SITE FOR RESIDUE FAD A 599

Chain	Residue
A	ASP208
A	GLY264
A	GLN265
A	THR266
A	GLY267
A	GLY279
A	ILE280
A	SER281
A	GLN285
A	HIS286
A	ASN300
A	GLY222
A	LYS301
A	ASP302
A	ALA317
A	ASP318
A	LEU319
A	HOH619
A	HOH634
B	LEU185
A	ARG223
A	GLY224
A	SER248
A	ARG249
A	ALA250
A	GLN262
A	VAL263

---

site_id	AC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE AMP B 600

Chain	Residue
B	ALA9
B	VAL10
B	LYS11
B	ASN39
B	CYS42
B	CYS66
B	VAL104
B	LEU122
B	GLY123
B	GLN125
B	ALA126
B	ASP129
B	CYS131
B	ASN132
B	GLN133
B	THR134
B	HOH617

---

Functional Information from PROSITE/UniProt

site_id	PS00696
Number of Residues	27
Details	ETF_ALPHA Electron transfer flavoprotein alpha-subunit signature. LYIAvGISGaIQHlaGmkdsktIvAIN

Chain	Residue	Details
A	LEU274-ASN300

---

site_id	PS01065
Number of Residues	21
Details	ETF_BETA Electron transfer flavoprotein beta-subunit signature. VeRaiDGGl.EtLrlklPaVVT

Chain	Residue	Details
B	VAL162-THR182

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	184
Details	Region: {"description":"Domain I","evidences":[{"source":"PubMed","id":"8962055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	128
Details	Region: {"description":"Domain II","evidences":[{"source":"PubMed","id":"8962055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15975918","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962055","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A1T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q99LC5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	5
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q99LC5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q99LC5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q99LC5","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	Region: {"description":"Recognition loop","evidences":[{"source":"PubMed","id":"15159392","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25023281","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15159392","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15975918","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8962055","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1EFV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T9G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2A1T","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"N6,N6,N6-trimethyllysine; by ETFBKMT","evidences":[{"source":"PubMed","id":"25023281","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25416781","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q9DCW4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DCW4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---