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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

28JV

Cryo-EM structure of the human holo-TFIIH-XPC complex bound to bulky lesion-mimic DNA (consensus map)

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DADGTGTIDvkEL
ChainResidueDetails
KASP41-LEU53
KASP150-PHE162
site_idPS00028
Number of Residues21
DetailsZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cav..CqnvFcvdcdvfvHdsl..H
ChainResidueDetails
ECYS360-HIS380
site_idPS00039
Number of Residues9
DetailsDEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. MIDEADRdG
ChainResidueDetails
KMET145-GLY153
site_idPS00518
Number of Residues10
DetailsZF_RING_1 Zinc finger RING-type signature. CgHtLCesCV
ChainResidueDetails
HCYS26-VAL35
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. AvVVFDEAHN
ChainResidueDetails
BALA229-ASN238
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues437
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues160
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues3
DetailsMotif: {"description":"DEVH box"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"33902107","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"7NVV","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"7NVX","evidenceCode":"ECO:0000312"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues199
DetailsRegion: {"description":"Mediates interaction with MMS19"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues13
DetailsMotif: {"description":"Nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues7
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31253769","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RO4","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9DBA9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues176
DetailsDomain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues34
DetailsZinc finger: {"description":"C4-type"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"A0JN27","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues159
DetailsRegion: {"description":"Minimal sensor domain involved in damage recognition"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues134
DetailsRegion: {"description":"DNA-binding; preference for heteroduplex DNA"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues64
DetailsRegion: {"description":"DNA-binding; preference for single stranded DNA; required for formation of stable nucleoprotein complex"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues19
DetailsRegion: {"description":"Interaction with CETN2"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues43
DetailsDomain: {"description":"STI1"}
ChainResidueDetails
site_idSWS_FT_FI25
Number of Residues35
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI26
Number of Residues5
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

253795

PDB entries from 2026-05-20

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