Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ZSV

Crystal structure of human NADP-dependent leukotriene B4 12-hydroxydehydrogenase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006691	biological_process	leukotriene metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
A	0032440	molecular_function	2-alkenal reductase [NAD(P)H] activity
A	0035798	molecular_function	2-alkenal reductase (NADPH) activity
A	0036102	biological_process	leukotriene B4 metabolic process
A	0036185	molecular_function	13-lipoxin reductase activity
A	0047522	molecular_function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity
A	0070062	cellular_component	extracellular exosome
A	0097257	molecular_function	leukotriene B4 12-hydroxy dehydrogenase activity
A	2001302	biological_process	lipoxin A4 metabolic process
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006691	biological_process	leukotriene metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
B	0032440	molecular_function	2-alkenal reductase [NAD(P)H] activity
B	0035798	molecular_function	2-alkenal reductase (NADPH) activity
B	0036102	biological_process	leukotriene B4 metabolic process
B	0036185	molecular_function	13-lipoxin reductase activity
B	0047522	molecular_function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity
B	0070062	cellular_component	extracellular exosome
B	0097257	molecular_function	leukotriene B4 12-hydroxy dehydrogenase activity
B	2001302	biological_process	lipoxin A4 metabolic process
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006691	biological_process	leukotriene metabolic process
C	0006693	biological_process	prostaglandin metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
C	0032440	molecular_function	2-alkenal reductase [NAD(P)H] activity
C	0035798	molecular_function	2-alkenal reductase (NADPH) activity
C	0036102	biological_process	leukotriene B4 metabolic process
C	0036185	molecular_function	13-lipoxin reductase activity
C	0047522	molecular_function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity
C	0070062	cellular_component	extracellular exosome
C	0097257	molecular_function	leukotriene B4 12-hydroxy dehydrogenase activity
C	2001302	biological_process	lipoxin A4 metabolic process
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006629	biological_process	lipid metabolic process
D	0006631	biological_process	fatty acid metabolic process
D	0006691	biological_process	leukotriene metabolic process
D	0006693	biological_process	prostaglandin metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016628	molecular_function	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
D	0032440	molecular_function	2-alkenal reductase [NAD(P)H] activity
D	0035798	molecular_function	2-alkenal reductase (NADPH) activity
D	0036102	biological_process	leukotriene B4 metabolic process
D	0036185	molecular_function	13-lipoxin reductase activity
D	0047522	molecular_function	15-oxoprostaglandin 13-reductase [NAD(P)+] activity
D	0070062	cellular_component	extracellular exosome
D	0097257	molecular_function	leukotriene B4 12-hydroxy dehydrogenase activity
D	2001302	biological_process	lipoxin A4 metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 401

Chain	Residue
D	ALA149
D	TYR193

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL B 402

Chain	Residue
B	TYR193

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 403

Chain	Residue
A	THR18
A	SER20
D	ASN19

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 404

Chain	Residue
B	ASN19
B	ALA311
C	SER20

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 405

Chain	Residue
C	VAL46
C	MET316
C	LYS324
C	THR325
C	HOH451

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 406

Chain	Residue
C	TYR193

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 407

Chain	Residue
A	TYR193

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 408

Chain	Residue
A	MET316
A	LYS324
A	THR325
A	HOH447

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 409

Chain	Residue
B	VAL46
B	LYS324
B	THR325

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 414

Chain	Residue
D	LYS324
D	THR325

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JAN-2011","submissionDatabase":"PDB data bank","title":"Crystal structure of human leukotriene B4 12-hydroxydehydrogenase in complex with NADP and raloxifene.","authoringGroup":["Structural genomics consortium (SGC)"]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q91YR9","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
A	LYS55

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
B	LYS55

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
C	LYS55

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1guf

Chain	Residue	Details
D	LYS55

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)