1ZBH

3'-end specific recognition of histone mRNA stem-loop by 3'-exonuclease

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0003676	molecular_function	nucleic acid binding
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0003676	molecular_function	nucleic acid binding
C	0000175	molecular_function	3'-5'-RNA exonuclease activity
C	0003676	molecular_function	nucleic acid binding
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0003676	molecular_function	nucleic acid binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 1000

Chain	Residue
A	ASP134
A	ASP234
A	MG1001
A	AMP1002

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 1001

Chain	Residue
A	ASP134
A	GLU136
A	ASP298
A	MG1000
A	AMP1002

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2000

Chain	Residue
B	ASP134
B	ASP230
B	ASP234
B	AMP2002

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 2001

Chain	Residue
B	ASP134
B	GLU136
B	ASP298
B	AMP2002

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG C 3000

Chain	Residue
C	ASP134
C	ASP234
C	AMP3002

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 3001

Chain	Residue
C	ASP134
C	GLU136
C	ASP298
C	AMP3002

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 4000

Chain	Residue
D	ASP134
D	ASP234
D	MG4001
D	AMP4002

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG D 4001

Chain	Residue
D	ASP134
D	GLU136
D	ASP298
D	MG4000
D	AMP4002

---

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE AMP A 1002

Chain	Residue
A	ASP134
A	PHE135
A	GLU136
A	ALA137
A	THR138
A	CYS139
A	ASN143
A	PHE185
A	PHE238
A	MG1000
A	MG1001

---

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE AMP B 2002

Chain	Residue
B	ASP134
B	PHE135
B	GLU136
B	ALA137
B	THR138
B	CYS139
B	GLU140
B	ASN143
B	PHE185
B	PHE238
B	ASN293
B	MG2000
B	MG2001

---

site_id	BC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE AMP C 3002

Chain	Residue
C	ASP134
C	PHE135
C	GLU136
C	ALA137
C	THR138
C	CYS139
C	ASN143
C	PHE185
C	LEU189
C	THR190
C	TRP233
C	PHE238
C	ASN293
C	MG3000
C	MG3001

---

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE AMP D 4002

Chain	Residue
D	ASP134
D	PHE135
D	GLU136
D	ALA137
D	THR138
D	CYS139
D	ASN143
D	PHE185
D	THR190
D	PHE238
D	MG4000
D	MG4001

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	68
Details	Domain: {"description":"SAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00186","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	704
Details	Domain: {"description":"Exonuclease"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"15451662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W0H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15451662","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1W0H","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
C	ASP134	metal ligand
C	GLU136	electrostatic stabiliser, metal ligand, proton acceptor
C	ASP234	metal ligand
C	ASN293	electrostatic stabiliser, proton acceptor
C	ASP298	metal ligand

---

site_id	MCSA2
Number of Residues	5
Details	M-CSA 784

Chain	Residue	Details
D	ASP134	metal ligand
D	GLU136	electrostatic stabiliser, metal ligand, proton acceptor
D	ASP234	metal ligand
D	ASN293	electrostatic stabiliser, proton acceptor
D	ASP298	metal ligand

---

site_id	MCSA3
Number of Residues	5
Details	M-CSA 784

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues	5
Details	M-CSA 784

Chain

Residue

Details

---