1Z25
Structure of P.furiosus Argonaute with bound Mn2+
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0004519 | molecular_function | endonuclease activity |
| A | 0004520 | molecular_function | DNA endonuclease activity |
| A | 0006259 | biological_process | DNA metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0044355 | biological_process | clearance of foreign intracellular DNA |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 771 |
| Chain | Residue |
| A | ASP558 |
| A | ASP628 |
| A | HIS745 |
| A | HOH774 |
| A | HOH781 |
| A | HOH788 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 283 |
| Details | Domain: {"description":"Piwi","evidences":[{"source":"PROSITE-ProRule","id":"PRU00150","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15284453","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15284453","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15800637","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"UniProtKB","id":"Q746M7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"15800637","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q746M7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q746M7","evidenceCode":"ECO:0000250"},{"source":"PubMed","id":"15800637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z25","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15800637","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Z25","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
