1YKB

Crystal Structure of Insect Cell Expressed IL-22

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005125	molecular_function	cytokine activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006953	biological_process	acute-phase response
A	0006954	biological_process	inflammatory response
A	0007165	biological_process	signal transduction
A	0045518	molecular_function	interleukin-22 receptor binding
A	0050728	biological_process	negative regulation of inflammatory response
A	0051384	biological_process	response to glucocorticoid
B	0005125	molecular_function	cytokine activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006953	biological_process	acute-phase response
B	0006954	biological_process	inflammatory response
B	0007165	biological_process	signal transduction
B	0045518	molecular_function	interleukin-22 receptor binding
B	0050728	biological_process	negative regulation of inflammatory response
B	0051384	biological_process	response to glucocorticoid
C	0005125	molecular_function	cytokine activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0006953	biological_process	acute-phase response
C	0006954	biological_process	inflammatory response
C	0007165	biological_process	signal transduction
C	0045518	molecular_function	interleukin-22 receptor binding
C	0050728	biological_process	negative regulation of inflammatory response
C	0051384	biological_process	response to glucocorticoid
D	0005125	molecular_function	cytokine activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0006953	biological_process	acute-phase response
D	0006954	biological_process	inflammatory response
D	0007165	biological_process	signal transduction
D	0045518	molecular_function	interleukin-22 receptor binding
D	0050728	biological_process	negative regulation of inflammatory response
D	0051384	biological_process	response to glucocorticoid
E	0005125	molecular_function	cytokine activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006953	biological_process	acute-phase response
E	0006954	biological_process	inflammatory response
E	0007165	biological_process	signal transduction
E	0045518	molecular_function	interleukin-22 receptor binding
E	0050728	biological_process	negative regulation of inflammatory response
E	0051384	biological_process	response to glucocorticoid
F	0005125	molecular_function	cytokine activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006953	biological_process	acute-phase response
F	0006954	biological_process	inflammatory response
F	0007165	biological_process	signal transduction
F	0045518	molecular_function	interleukin-22 receptor binding
F	0050728	biological_process	negative regulation of inflammatory response
F	0051384	biological_process	response to glucocorticoid

Functional Information from PROSITE/UniProt

site_id	PS00520
Number of Residues	21
Details	INTERLEUKIN_10 Interleukin-10 family signature. SmserCYlmkqVLnFTLeEVL

Chain	Residue	Details
A	SER84-LEU104

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15983417","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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