1YFJ

T4Dam in Complex with AdoHcy and 15-mer Oligonucleotide Showing Semi-specific and Specific Contact

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0006260	biological_process	DNA replication
A	0006298	biological_process	mismatch repair
A	0008168	molecular_function	methyltransferase activity
A	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
A	0009008	molecular_function	DNA-methyltransferase activity
A	0009307	biological_process	DNA restriction-modification system
A	0019049	biological_process	virus-mediated perturbation of host defense response
A	0032259	biological_process	methylation
A	0043565	molecular_function	sequence-specific DNA binding
A	0052170	biological_process	symbiont-mediated suppression of host innate immune response
A	0099018	biological_process	symbiont-mediated evasion of host restriction-modification system
A	1904047	molecular_function	S-adenosyl-L-methionine binding
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0006260	biological_process	DNA replication
B	0006298	biological_process	mismatch repair
B	0008168	molecular_function	methyltransferase activity
B	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
B	0009008	molecular_function	DNA-methyltransferase activity
B	0009307	biological_process	DNA restriction-modification system
B	0019049	biological_process	virus-mediated perturbation of host defense response
B	0032259	biological_process	methylation
B	0043565	molecular_function	sequence-specific DNA binding
B	0052170	biological_process	symbiont-mediated suppression of host innate immune response
B	0099018	biological_process	symbiont-mediated evasion of host restriction-modification system
B	1904047	molecular_function	S-adenosyl-L-methionine binding
C	0003676	molecular_function	nucleic acid binding
C	0003677	molecular_function	DNA binding
C	0006260	biological_process	DNA replication
C	0006298	biological_process	mismatch repair
C	0008168	molecular_function	methyltransferase activity
C	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
C	0009008	molecular_function	DNA-methyltransferase activity
C	0009307	biological_process	DNA restriction-modification system
C	0019049	biological_process	virus-mediated perturbation of host defense response
C	0032259	biological_process	methylation
C	0043565	molecular_function	sequence-specific DNA binding
C	0052170	biological_process	symbiont-mediated suppression of host innate immune response
C	0099018	biological_process	symbiont-mediated evasion of host restriction-modification system
C	1904047	molecular_function	S-adenosyl-L-methionine binding
D	0003676	molecular_function	nucleic acid binding
D	0003677	molecular_function	DNA binding
D	0006260	biological_process	DNA replication
D	0006298	biological_process	mismatch repair
D	0008168	molecular_function	methyltransferase activity
D	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
D	0009008	molecular_function	DNA-methyltransferase activity
D	0009307	biological_process	DNA restriction-modification system
D	0019049	biological_process	virus-mediated perturbation of host defense response
D	0032259	biological_process	methylation
D	0043565	molecular_function	sequence-specific DNA binding
D	0052170	biological_process	symbiont-mediated suppression of host innate immune response
D	0099018	biological_process	symbiont-mediated evasion of host restriction-modification system
D	1904047	molecular_function	S-adenosyl-L-methionine binding
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0006260	biological_process	DNA replication
E	0006298	biological_process	mismatch repair
E	0008168	molecular_function	methyltransferase activity
E	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
E	0009008	molecular_function	DNA-methyltransferase activity
E	0009307	biological_process	DNA restriction-modification system
E	0019049	biological_process	virus-mediated perturbation of host defense response
E	0032259	biological_process	methylation
E	0043565	molecular_function	sequence-specific DNA binding
E	0052170	biological_process	symbiont-mediated suppression of host innate immune response
E	0099018	biological_process	symbiont-mediated evasion of host restriction-modification system
E	1904047	molecular_function	S-adenosyl-L-methionine binding
F	0003676	molecular_function	nucleic acid binding
F	0003677	molecular_function	DNA binding
F	0006260	biological_process	DNA replication
F	0006298	biological_process	mismatch repair
F	0008168	molecular_function	methyltransferase activity
F	0009007	molecular_function	site-specific DNA-methyltransferase (adenine-specific) activity
F	0009008	molecular_function	DNA-methyltransferase activity
F	0009307	biological_process	DNA restriction-modification system
F	0019049	biological_process	virus-mediated perturbation of host defense response
F	0032259	biological_process	methylation
F	0043565	molecular_function	sequence-specific DNA binding
F	0052170	biological_process	symbiont-mediated suppression of host innate immune response
F	0099018	biological_process	symbiont-mediated evasion of host restriction-modification system
F	1904047	molecular_function	S-adenosyl-L-methionine binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL 8 600

Chain	Residue
4	DT401

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL 1 602

Chain	Residue
1	DT101

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL 2 603

Chain	Residue
2	DT201

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA 2 502

Chain	Residue
B	HOH503
B	HOH504
1	HOH604
1	HOH605
1	HOH607
2	HOH606
2	HOH609
B	HOH502

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CA 4 508

Chain	Residue
3	HOH612
3	HOH613
3	HOH615
4	HOH614
4	HOH619
A	HOH497
A	HOH498
A	HOH499

---

site_id	AC6
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH A 401

Chain	Residue
A	TYR7
A	ASN10
A	LYS11
A	LEU31
A	PHE32
A	CYS33
A	GLY34
A	GLY35
A	SER37
A	ASP50
A	ILE51
A	GLN52
A	HIS156
A	PHE157
A	ASP171
A	PRO173
A	TYR181
A	PHE184
A	HOH427
A	HOH489
C	HOH461

---

site_id	AC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH B 402

Chain	Residue
A	HOH490
B	TYR7
B	ASN10
B	LYS11
B	PHE32
B	CYS33
B	GLY34
B	GLY35
B	SER37
B	ASP50
B	ILE51
B	GLN52
B	HIS156
B	PHE157
B	ASP171
B	PRO173
B	TYR181
B	PHE184
B	HOH422
B	HOH437

---

site_id	AC8
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAH C 403

Chain	Residue
B	HOH462
C	TYR7
C	GLY9
C	ASN10
C	LYS11
C	PHE32
C	CYS33
C	GLY34
C	GLY35
C	SER37
C	ASP50
C	ILE51
C	GLN52
C	HIS156
C	PHE157
C	ASP171
C	PRO173
C	TYR181
C	PHE184
C	HOH408
C	HOH418

---

site_id	AC9
Number of Residues	19
Details	BINDING SITE FOR RESIDUE SAH D 404

Chain	Residue
D	HOH412
D	TYR7
D	ASN10
D	LYS11
D	PHE32
D	CYS33
D	GLY34
D	GLY35
D	SER37
D	ASP50
D	ILE51
D	GLN52
D	LEU155
D	HIS156
D	PHE157
D	ASP171
D	PRO173
D	TYR181
D	PHE184

---

site_id	BC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE SAH E 405

Chain	Residue
E	TYR7
E	ASN10
E	LYS11
E	LEU31
E	PHE32
E	CYS33
E	GLY34
E	GLY35
E	SER37
E	VAL38
E	ASP50
E	ILE51
E	GLN52
E	HIS156
E	PHE157
E	ASP171
E	TYR181
E	PHE184
E	HOH408
E	HOH416

---

site_id	BC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE SAH F 406

Chain	Residue
F	TYR7
F	GLY9
F	ASN10
F	LYS11
F	LEU31
F	PHE32
F	CYS33
F	GLY34
F	GLY35
F	LEU36
F	SER37
F	ASN49
F	ASP50
F	ILE51
F	HIS156
F	PHE157
F	ASP171
F	TYR181

---

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. VYVDPPY

Chain	Residue	Details
A	VAL168-TYR174

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	BINDING: BINDING => ECO:0007744|PDB:1Q0S, ECO:0007744|PDB:1Q0T, ECO:0007744|PDB:1YF3, ECO:0007744|PDB:1YFJ

Chain	Residue	Details
A	TYR7
C	PHE32
C	ASP50
C	TYR181
D	TYR7
D	PHE32
D	ASP50
D	TYR181
E	TYR7
E	PHE32
E	ASP50
A	PHE32
E	TYR181
F	TYR7
F	PHE32
F	ASP50
F	TYR181
A	ASP50
A	TYR181
B	TYR7
B	PHE32
B	ASP50
B	TYR181
C	TYR7

---

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0007744|PDB:1Q0S, ECO:0007744|PDB:1YF3, ECO:0007744|PDB:1YFJ

Chain	Residue	Details
A	LYS11
D	LYS11
D	HIS156
D	ASP171
E	LYS11
E	HIS156
E	ASP171
F	LYS11
F	HIS156
F	ASP171
A	HIS156
A	ASP171
B	LYS11
B	HIS156
B	ASP171
C	LYS11
C	HIS156
C	ASP171

---